The Relation Between Lp-PLA2 Levels with Periodic Limb Movements
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGER HEIDELBERG
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Lipoprotein-associated phospholipase A2 (Lp-PLA2), a novel marker of vulnerable plaque to prone rupture, is a predictor of both cardiovascular event and cerebrovascular event, and highly sensitive-C-reactive protein (hs-CRP) is an acute-phase response protein implicated in a broad range of cardiovascular diseases. We aimed to examine the association between periodic limb movements in sleep (PLMs) with circulating Lp-PLA2 and hs-CRP levels in patients with PLMs. Seventy patients with newly diagnosed PLM with polysomnography were enrolled this study. Patients were divided into two groups according to PLM index (normal PLM index, < 15; elevated PLM index, a parts per thousand yen15). Lp-PLA2 and hs-CRP concentrations were measured in serum samples by turbidimetric and nephelometric methods, respectively. The concentrations of these parameters were compared between two groups and correlation analysis was performed between PLMs and Lp-PLA2 and hs-CRP levels. Lp-PLA2 levels and hs-CRP were significantly increased in elevated PLM index group compared with the control group (206.8 +/- 78.1 vs 157.8 +/- 56.7, p = 0.003, and 4.2 +/- 3.5 vs 2.4 +/- 2.1, p = 0.02, respectively). PLM index was positively correlated with Lp-PLA2 levels (r = 0.40, p = 0.001) and hs-CRP (r = 0.24, p = 0.05). In the linear regression model, Lp-PLA2 was an independent predictor of PLM index (R (2) = 0.36, p = 0.005). This study demonstrated an independent linear relation between PLM index and Lp-PLA2. In addition, it was seen increased Lp-PLA2 and hs-CRP levels in patients with elevated PLM index. Based on these results, we can suggest that risk of vascular events may be increased in patients with PLMs and with increased PLM index.
Açıklama
Anahtar Kelimeler
Lipoprotein-Associated Phospholipase A2, Hs-CRP, Cardiovascular Risk, Periodic Limb Movements
Kaynak
Sleep and Breathing
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
16
Sayı
1
Künye
Bekçi, T. T., Kayrak, M., Kıyıcı, A., Arı, H., Teke, T., Maden, E., Akıllı, H., (2012). The Relation Between Lp-PLA2 Levels with Periodic Limb Movements. Sleep and Breathing, 16(1), 117-122. DOI: 10.1007/s11325-010-0464-y
