The Relation Between Lp-PLA2 Levels with Periodic Limb Movements

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dc.contributor.authorBekçi, Taha Tahir
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorKıyıcı, Aysel
dc.contributor.authorArı, Hatem
dc.contributor.authorTeke, Turgut
dc.contributor.authorMaden, Emin
dc.contributor.authorAkıllı, Hakan
dc.date.accessioned2020-03-26T18:31:50Z
dc.date.available2020-03-26T18:31:50Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractLipoprotein-associated phospholipase A2 (Lp-PLA2), a novel marker of vulnerable plaque to prone rupture, is a predictor of both cardiovascular event and cerebrovascular event, and highly sensitive-C-reactive protein (hs-CRP) is an acute-phase response protein implicated in a broad range of cardiovascular diseases. We aimed to examine the association between periodic limb movements in sleep (PLMs) with circulating Lp-PLA2 and hs-CRP levels in patients with PLMs. Seventy patients with newly diagnosed PLM with polysomnography were enrolled this study. Patients were divided into two groups according to PLM index (normal PLM index, < 15; elevated PLM index, a parts per thousand yen15). Lp-PLA2 and hs-CRP concentrations were measured in serum samples by turbidimetric and nephelometric methods, respectively. The concentrations of these parameters were compared between two groups and correlation analysis was performed between PLMs and Lp-PLA2 and hs-CRP levels. Lp-PLA2 levels and hs-CRP were significantly increased in elevated PLM index group compared with the control group (206.8 +/- 78.1 vs 157.8 +/- 56.7, p = 0.003, and 4.2 +/- 3.5 vs 2.4 +/- 2.1, p = 0.02, respectively). PLM index was positively correlated with Lp-PLA2 levels (r = 0.40, p = 0.001) and hs-CRP (r = 0.24, p = 0.05). In the linear regression model, Lp-PLA2 was an independent predictor of PLM index (R (2) = 0.36, p = 0.005). This study demonstrated an independent linear relation between PLM index and Lp-PLA2. In addition, it was seen increased Lp-PLA2 and hs-CRP levels in patients with elevated PLM index. Based on these results, we can suggest that risk of vascular events may be increased in patients with PLMs and with increased PLM index.en_US
dc.identifier.citationBekçi, T. T., Kayrak, M., Kıyıcı, A., Arı, H., Teke, T., Maden, E., Akıllı, H., (2012). The Relation Between Lp-PLA2 Levels with Periodic Limb Movements. Sleep and Breathing, 16(1), 117-122. DOI: 10.1007/s11325-010-0464-y
dc.identifier.doi10.1007/s11325-010-0464-yen_US
dc.identifier.endpage122en_US
dc.identifier.issn1520-9512en_US
dc.identifier.issn1522-1709en_US
dc.identifier.issue1en_US
dc.identifier.pmid21221825en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11325-010-0464-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28550
dc.identifier.volume16en_US
dc.identifier.wosWOS:000300324600017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKayrak, Mehmet
dc.institutionauthorKıyıcı, Aysel
dc.institutionauthorArı, Hatem
dc.institutionauthorTeke, Turgut
dc.institutionauthorMaden, Emin
dc.institutionauthorAkıllı, Hakan
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofSleep and Breathingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLipoprotein-Associated Phospholipase A2en_US
dc.subjectHs-CRPen_US
dc.subjectCardiovascular Risken_US
dc.subjectPeriodic Limb Movementsen_US
dc.titleThe Relation Between Lp-PLA2 Levels with Periodic Limb Movementsen_US
dc.typeArticleen_US

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