Rapid and real-time detection of arginine enantiomers by QCM sensor having a Calix[4]arene receptor bearing asymmetric centers
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This paper describes the sensing studies of a chiral calix[4]arene receptor (5) having (R)-2-phenylglycinol moiety for arginine enantiomers (D-/L-arginine) by using Quartz Crystal Microbalance (QCM) technique. The initial experiments have revealed that the chiral calix[4]arene 5 coated QCM (CCC-QCM) sensor showed good sensing for arginine enantiomers, such that it has exhibited higher sensing towards D-arginine than that of L-arginine. It has been determined that the sensitivity, limit of detection values of CCC-QCM sensor for the D-/L-arginine solutions as 0.024/0.023 Hz/mu M and 0.38/1.29 mu M, respectively. On the other hand, the racemic mixture studies were optimized using the response surface methodology with central composite design. Consequently, it has been demonstrated that the QCM sensor modification with a calix[4]arene receptor bearing asymmetric centers provided rapid, real-time, sensitive and effective sensing of arginine enantiomers.
Açıklama
Anahtar Kelimeler
Arginine, Calixarene, Sensing, Quartz crystal microbalance, Sensor, Amino acid
Kaynak
TALANTA
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
204
Sayı
Künye
Temel, F., Erdemir, S., Ozcelik, E., Tabakci, B.,Tabakci, M. (2019). Rapid And Real-Time Detection Of Arginine Enantiomers By QCM Sensor Having A Calix [4] Arene Receptor Bearing Asymmetric Centers. Talanta, 204, 172-181.
