In-situ growth of NiWO4 saw-blade-like nanostructures and their application in photo-electrochemical (PEC) immunosensor system designed for the detection of neuron-specific enolase

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dc.contributor.authorSoomro, Razium Ali
dc.contributor.authorKalwar, Nazar Hussain
dc.contributor.authorAvci, Ahmet
dc.contributor.authorPehlivan, Erol
dc.contributor.authorHallam, Keith Richard
dc.contributor.authorWillander, Magnus
dc.date.accessioned2020-03-26T20:14:47Z
dc.date.available2020-03-26T20:14:47Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümüen_US
dc.description.abstractThis study describes the construction of highly-sensitive photo-electrochemical (PEC) immunosensor for the detection of neuron-specific enolase (NSE). The biosensing platform is comprised of photo-active NiWO4 nanostructures, in-situ-grown over a conductive substrate (indium tin oxide) using a low-temperature template-based co-precipitation approach. The discussed approach enables the formation of discrete, yet morphologically-analogous, nanostructures with complete coverage (pinhole-free) of the electrode surface. The in-situ-grown nanostructure possess dense population with sharp saw-blade like morphological features that can support substantial immobilisation of anti-NSE agent. The constructed platform demonstrated excellent photo-catalytic activity towards uric acid (UA) which served as the base for the Electrochemical -mechanism (EC) based PEC inhibition sensing. The detection of NSE, relied on its obstruction in analytical signal observed for the photo-oxidation of UA after binding to the electrode surface via protein-antibody interaction. The constructed PEC immunosensor exhibits signal sensitivity up to 0.12 ng mL(-1) of NSE with excellent signal reproducibility and electrode replicability. Moreover, the constructed platform was successfully used for NSE determination in human serum samples.en_US
dc.identifier.citationSoomro, R. A., Kalwar, N. H., Avci, A., Pehlivan, E., Hallam, K. R., Willander, M. (2019). In-Situ Growth Of Niwo4 Saw-Blade-Like Nanostructures And Their Application İn Photo-Electrochemical (PEC) İmmunosensor System Designed For The Detection Of Neuron-Specific Enolase. Biosensors And Bioelectronics, 141, 1-7.
dc.identifier.doi10.1016/j.bios.2019.111331en_US
dc.identifier.issn0956-5663en_US
dc.identifier.issn1873-4235en_US
dc.identifier.pmid31233985en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.bios.2019.111331
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37935
dc.identifier.volume141en_US
dc.identifier.wosWOS:000486132800032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvci, Ahmet
dc.institutionauthorPehlivan, Erol
dc.language.isoenen_US
dc.publisherELSEVIER ADVANCED TECHNOLOGYen_US
dc.relation.ispartofBIOSENSORS & BIOELECTRONICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNiWO4 nanostructuresen_US
dc.subjectNeuron-specific enolaseen_US
dc.subjectIndium tin oxide electrodeen_US
dc.subjectBiosensoren_US
dc.titleIn-situ growth of NiWO4 saw-blade-like nanostructures and their application in photo-electrochemical (PEC) immunosensor system designed for the detection of neuron-specific enolaseen_US
dc.typeArticleen_US

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