Curcumin increases vasodilatory effect of cilostazol in diabetic rat aorta
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NATL INST SCIENCE COMMUNICATION-NISCAIR
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Increased generation of oxidants and (or) reduced endogenous antioxidant defense mechanisms are associated with the etiology of diabetic vascular complications. The aim of the present study was to evaluate whether curcumin supplementation increases the vasodilatory effect of cilostazol in streptozotocin induced diabetic rat aorta. Cumulative addition of cilostazol caused concentration-dependent relaxations of thoracic aorta rings. The sensitivity and the maximal response to cilostazol were significantly higher in control than those in diabetic animals. Treatment with curcurnin in control rats increased the sensitivity to cilostazol. Further, in aortic rings from diabetic rats treated with curcumin, the responses to cilostazol were significantly increased in comparison to the response in aorta from untreated diabetic rats. It can be conclude, that curcurnin increases the cilostazol-induced vasodilation in diabetic rat aorta.
Açıklama
Anahtar Kelimeler
Aorta, Cilostazol, Curcumin, Diabetes
Kaynak
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
50
Sayı
2
