Curcumin increases vasodilatory effect of cilostazol in diabetic rat aorta

Basit Öğe Kaydı
dc.contributor.authorAtalık, Kısmet Esra Nurullahoğlu
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBelviranlı, Muaz
dc.contributor.authorGökbel, Hakkı
dc.contributor.authorŞimşek, L.
dc.date.accessioned2020-03-26T18:24:35Z
dc.date.available2020-03-26T18:24:35Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIncreased generation of oxidants and (or) reduced endogenous antioxidant defense mechanisms are associated with the etiology of diabetic vascular complications. The aim of the present study was to evaluate whether curcumin supplementation increases the vasodilatory effect of cilostazol in streptozotocin induced diabetic rat aorta. Cumulative addition of cilostazol caused concentration-dependent relaxations of thoracic aorta rings. The sensitivity and the maximal response to cilostazol were significantly higher in control than those in diabetic animals. Treatment with curcurnin in control rats increased the sensitivity to cilostazol. Further, in aortic rings from diabetic rats treated with curcumin, the responses to cilostazol were significantly increased in comparison to the response in aorta from untreated diabetic rats. It can be conclude, that curcurnin increases the cilostazol-induced vasodilation in diabetic rat aorta.en_US
dc.description.sponsorshipScientific Research Foundation of Selcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Foundation of Selcuk University.en_US
dc.identifier.endpage132en_US
dc.identifier.issn0019-5189en_US
dc.identifier.issn0975-1009en_US
dc.identifier.issue2en_US
dc.identifier.pmid22670475en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27873
dc.identifier.volume50en_US
dc.identifier.wosWOS:000300136800005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATL INST SCIENCE COMMUNICATION-NISCAIRen_US
dc.relation.ispartofINDIAN JOURNAL OF EXPERIMENTAL BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAortaen_US
dc.subjectCilostazolen_US
dc.subjectCurcuminen_US
dc.subjectDiabetesen_US
dc.titleCurcumin increases vasodilatory effect of cilostazol in diabetic rat aortaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu