Splenic artery embolization with Ankaferd blood stopper in a sheep model

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dc.contributor.authorKoc, Osman
dc.contributor.authorAcar, Kadir
dc.contributor.authorOzbek, Orhan
dc.contributor.authorGuler, Ibrahim
dc.contributor.authorSaritas, Kadir
dc.contributor.authorErdem, Tuba Bera
dc.contributor.authorSolak, Yalcin
dc.date.accessioned2020-03-26T19:26:35Z
dc.date.available2020-03-26T19:26:35Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPURPOSE Splenic artery embolization is a minimally invasive therapeutic procedure utilized in a number of disorders. Ankaferd blood stopper (ABS) is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We aimed to investigate the safety and efficiency of ABS for splenic artery embolization in a sheep model. METHODS Seven adult female sheep were included in the study. Selective celiac angiography was performed using a 5F diagnostic catheter and then a 2.7F hydrophilic coating microcatheter was advanced coaxially to the distal part of the main splenic artery. Under fluoroscopic guidance, 6 mL mixture composed of half-and-half ABS and contrast agent was slowly injected. Fluoroscopy was used to observe the deceleration and stagnation of the flow. Control celiac angiograms were obtained immediately after the embolization. After the procedure, the animals were observed for one day and then sacrificed with intravenous sodium thiopental. RESULTS Technical success rate was 100%. None of the animals died or experienced a major systemic adverse event during the procedure. All of the spleens appeared dark on macroscopic examination due to excessive thrombosis. Microscopically, the majority of the splenic sinusoids (90%-95%) were necrotic. CONCLUSION In our study, splenic artery embolization by ABS was found to be safe and effective in the short-term. Further studies are needed to better understand the embolizing potential of this novel hemostatic agent.en_US
dc.description.sponsorshipGenc Medicalen_US
dc.description.sponsorshipThe authors thank Genc Medical for financial support of the study.en_US
dc.identifier.doi10.5152/dir.2015.15382en_US
dc.identifier.endpage357en_US
dc.identifier.issn1305-3612en_US
dc.identifier.issue4en_US
dc.identifier.pmid27306661en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage354en_US
dc.identifier.urihttps://dx.doi.org/10.5152/dir.2015.15382
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34027
dc.identifier.volume22en_US
dc.identifier.wosWOS:000379846300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofDIAGNOSTIC AND INTERVENTIONAL RADIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleSplenic artery embolization with Ankaferd blood stopper in a sheep modelen_US
dc.typeArticleen_US

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