Long-term outcomes in pediatric appendiceal carcinoids: Turkey experience
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGER
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The tendency of non-operative management of appendicitis let us explore the natural history of appendiceal carcinoids, compare them with appendicitis patients, and determine the possibility of deciding the extent of the surgery and post-operative follow-up on behalf of the intraoperative findings. A retrospective review was performed of patients with appendicitis between 2009 and 2017. Of 2781 patients, 10 (0.36%) were diagnosed with appendiceal carcinoids. Sixty percent were female with an average age of 13.101.73. The mean tumor size was 0.97 +/- 0.34cm with 70% located at the tip. Majority had an insular pattern (n=9), six had subserosal fat tissue invasion, one had extension to mesoappendix, one had vascular invasion, and two had lymphatic invasion. The average mitotic index was 3.20 +/- 1.40/50HPF, and Ki 67 activity was 3 +/- 1.7%. The mean follow-up period was 66.40 +/- 25.92months. Patients were further evaluated with ultrasonography (n=10), CT (n=3), and MRI (n=10). Serum markers including chromogranin (n=9), NSE (n=6), and 5-HIAA (n=6) were normal. None required further treatment and had any symptoms of carcinoid syndromes or recurrences post-operatively.p id=Par2 Conclusion: Other than appendectomy, no additional surgery or follow-up is required in appendiceal carcinoids less than 1.5cm in size, regardless of the lymphoid or vascular invasion.
Açıklama
Anahtar Kelimeler
Appendicitis, Carcinoid tumor, Children, Neuroendocrine tumors
Kaynak
EUROPEAN JOURNAL OF PEDIATRICS
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
177
Sayı
12
