Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE BV
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ceftriaxone (CTX) is a third-generation cephalosporin that has proven to be effective in the treatment of infections caused by a wide range of gram-positive and gram-negative microorganisms. This study aimed to determine the plasma and muscle pharmacokinetics of CTX after its administration via the intravenous (IV) and intramuscular (IM) routes to brown trout (Salmo trutta fario) at temperatures of 10 degrees C-13 degrees C. In total, 140 healthy brown trout (body weight, 245 +/- 38 g) were used. The brown trout received single IV and IM injections of CTX at 25 mg/kg. The IV doses were injected into the caudal vein, whereas the IM doses were injected into the right epaxial muscles. The plasma and muscle tissue concentrations of CTX were measured using high-performance liquid chromatography. Pharmacokinetic parameters were calculated using noncompartmental methods. Following the IV administration of CTX, the elimination half-life (t<INF>1/2</INF><INF>(sic)z</INF>), volume of distribution at steady state, total body clearance, and area under the concentration-time curve (AUC<INF>0-72</INF>) in plasma were 5.83 h, 0.09 L/kg, 0.02 L/h/kg, and 1079.46 h*mu g/mL, respectively. After the IM administration of CTX, plasma t<INF>1/2(sic)z</INF>, peak plasma concentration (C<INF>max</INF>), time to reach C<INF>max</INF>, and bioavailability were 22.78 h, 87.92 mu g/mL, 0.5 h, and 27.19%, respectively. The AUC<INF>muscle</INF>/AHC<INF>plasma</INF> ratio following the IV administration was 0.02 and that following the IM administration was 0.04. CTX exhibited low bioavailability and prolonged t<INF>1/2</INF><INF><INF>(sic)</INF>z</INF> after the IM administration. The prolonged t<INF>1/2</INF><INF>(sic)z</INF> of CTX could thus be beneficial in brown trout. Nevertheless, future studies that aim to determine the clinical efficacy and pharmacokinetics after repeated administration of CTX are warranted.
Açıklama
Anahtar Kelimeler
Ceftriaxone, Brown trout, Pharmacokinetics, Bioavailability
Kaynak
AQUACULTURE
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
500
Sayı
Künye
Corum, O., Er, A., Corum, D. D., Atik, O., Uney, K. (2019). Pharmacokinetics and Bioavailability of Ceftriaxone in Brown Trout (Salmo trutta fario) After Intravenous and Intramuscular Administration. Aquaculture, 500, 272-277.
