Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration

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dc.contributor.authorCorum, Orhan.
dc.contributor.authorEr, Ayse.
dc.contributor.authorCorum, Duygu Durna.
dc.contributor.authorAtik, Orkun.
dc.contributor.authorUney, Kamil.
dc.date.accessioned2020-03-26T20:19:07Z
dc.date.available2020-03-26T20:19:07Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractCeftriaxone (CTX) is a third-generation cephalosporin that has proven to be effective in the treatment of infections caused by a wide range of gram-positive and gram-negative microorganisms. This study aimed to determine the plasma and muscle pharmacokinetics of CTX after its administration via the intravenous (IV) and intramuscular (IM) routes to brown trout (Salmo trutta fario) at temperatures of 10 degrees C-13 degrees C. In total, 140 healthy brown trout (body weight, 245 +/- 38 g) were used. The brown trout received single IV and IM injections of CTX at 25 mg/kg. The IV doses were injected into the caudal vein, whereas the IM doses were injected into the right epaxial muscles. The plasma and muscle tissue concentrations of CTX were measured using high-performance liquid chromatography. Pharmacokinetic parameters were calculated using noncompartmental methods. Following the IV administration of CTX, the elimination half-life (t<INF>1/2</INF><INF>(sic)z</INF>), volume of distribution at steady state, total body clearance, and area under the concentration-time curve (AUC<INF>0-72</INF>) in plasma were 5.83 h, 0.09 L/kg, 0.02 L/h/kg, and 1079.46 h*mu g/mL, respectively. After the IM administration of CTX, plasma t<INF>1/2(sic)z</INF>, peak plasma concentration (C<INF>max</INF>), time to reach C<INF>max</INF>, and bioavailability were 22.78 h, 87.92 mu g/mL, 0.5 h, and 27.19%, respectively. The AUC<INF>muscle</INF>/AHC<INF>plasma</INF> ratio following the IV administration was 0.02 and that following the IM administration was 0.04. CTX exhibited low bioavailability and prolonged t<INF>1/2</INF><INF><INF>(sic)</INF>z</INF> after the IM administration. The prolonged t<INF>1/2</INF><INF>(sic)z</INF> of CTX could thus be beneficial in brown trout. Nevertheless, future studies that aim to determine the clinical efficacy and pharmacokinetics after repeated administration of CTX are warranted.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Selcuk, Turkey [16401134]en_US
dc.description.sponsorshipThis work was supported by the Coordination of Scientific Research Projects, University of Selcuk, Turkey (project No. 16401134).en_US
dc.identifier.citationCorum, O., Er, A., Corum, D. D., Atik, O., Uney, K. (2019). Pharmacokinetics and Bioavailability of Ceftriaxone in Brown Trout (Salmo trutta fario) After Intravenous and Intramuscular Administration. Aquaculture, 500, 272-277.
dc.identifier.doi10.1016/j.aquaculture.2018.10.026en_US
dc.identifier.endpage277en_US
dc.identifier.issn0044-8486en_US
dc.identifier.issn1873-5622en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage272en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.aquaculture.2018.10.026
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38079
dc.identifier.volume500en_US
dc.identifier.wosWOS:000452969500033en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorEr, Ayse.
dc.institutionauthorUney, Kamil.
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofAQUACULTUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCeftriaxoneen_US
dc.subjectBrown trouten_US
dc.subjectPharmacokineticsen_US
dc.subjectBioavailabilityen_US
dc.titlePharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administrationen_US
dc.typeArticleen_US

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