The Relationship Between Epicardial Adipose Tissue and Coronary Artery Calcification in Peritoneal Dialysis Patients
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Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
KARGER
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Atherosclerosis, endothelial dysfunction, coronary artery calcification (CAC), and left ventricular hypertrophy are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in end-stage renal disease patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT has been shown in healthy subjects and patients with a high risk of coronary artery disease. In the present study, we aimed to investigate the relationship between EAT and CAC in peritoneal dialysis (PD) patients. Patients and Methods: Forty-five PD patients (18 females, 27 males, with a mean age of 50.6 +/- 15 years) and 25 healthy subjects (12 females, 13 males, with a mean age of 52.4 +/- 10.7 years) were enrolled in the study. EAT and CAC score (CACS) measurements were performed by a multidetector computed tomography scanner. Results: EAT of the PD patients was significantly higher than that of the healthy subjects (p = 0.02). When patients were divided into two subgroups (group 1: CACS <= 10, n = 20; group 2: CACS >10, n = 25), EAT was also significantly higher in group 2 patients than in group 1 patients and healthy subjects. Age and EAT were also found to be correlated with CACS >= 10. Conclusion: There is a relationship between the anatomic assessment of coronary artery lesions by multidetector computed tomography and EAT in PD patients. This relationship might be attributed to increased inflammation and proinflammatory cytokines in uremic patients.
Açıklama
Anahtar Kelimeler
Peritoneal Dialysis, Epicardial Adipose Tissue, Coronary Artery Calcification, End-Stage Renal Disease
Kaynak
Cardiorenal Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
2
Sayı
1
Künye
Türkmen, K., Özbek, O., Kayıkçıoğlu, H., Kayrak, M., Solak, Y., Nayman, A., Anıl, M., Babur, H., Tonbul, H. Z., (2012). The Relationship Between Epicardial Adipose Tissue and Coronary Artery Calcification in Peritoneal Dialysis Patients. Cardiorenal Medicine, 2(1), 43-51. DOI: 10.1159/000335495