Bone mineral density in emphysema and chronic bronchitis phenotypes in hospitalized male chronic obstructive pulmonary disease patients

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dc.authorid0000-0001-6563-8337
dc.contributor.authorYormaz, Burcu
dc.contributor.authorCebeci, Hakan
dc.contributor.authorYılmaz, Farise
dc.contributor.authorSüerdem, Mecit
dc.date.accessioned2020-03-26T20:20:09Z
dc.date.available2020-03-26T20:20:09Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction Risk of osteoporosis known to increase in chronic obstructive pulmonary disease (COPD), but is usually overlooked, especially in male patients. Objectives The present study compares the bone mineral density (BMD) measurements of male COPD patients with emphysema and the chronic bronchitis phenotype, and evaluates the association between density of emphysema and osteoporosis. Methods Ninety-four patients with COPD, and with emphysema and the chronic bronchitis phenotype, were included in the prospective study. A high-resolution computed tomography (HRCT) was used for the diagnosis of emphysema, and a dual X-ray absorptiometry was used to measure the BMD of the lumbar vertebrae and neck of the femur. Results Emphysema phenotype 45.75% and chronic bronchitis phenotype 54.25%, based on their clinical findings and a quantitative volumetric analysis by HRCT. Osteoporosis was found 60.47% and 17.65% of patients with emphysema and bronchitis, while osteopenia was detected 27.91% and 41.18% of patients with emphysema and bronchitis, respectively. A negative correlation was found between HRCT emphysema density and the bone densitometer t-score in patients with osteoporosis. Among the patients with osteoporosis, a positive correlation was found between Body Mass Index (BMI) and the bone densitometer t-score. Only BMI and emphysema score were found to be independent risk factors for a low BMD. One unit drop in BMI increased the risk of osteoporosis by 28% (OR = 1.28, 95% CI 1.14-1.45) (P < 0.001). One unit increase in emphysema score increased the risk of osteoporosis by 6% (OR = 1.06, 95% CI 1.03-1.09) (P < 0.001). Conclusion Especially male patients with emphysema, high dyspnea score, low BMI and frequent exacerbations should be evaluated for osteoporosis.en_US
dc.identifier.citationYormaz, B., Cebeci, H., Yılmaz, F., Süerdem, M. (2020). Bone Mineral Density in Emphysema and Chronic Bronchitis Phenotypes in Hospitalized Male Chronic Obstructive Pulmonary Disease Patients. Clinical Respiratory Journal, 14(1), 47-53.
dc.identifier.doi10.1111/crj.13099en_US
dc.identifier.endpage53en_US
dc.identifier.issn1752-6981en_US
dc.identifier.issn1752-699Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid31628822en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://dx.doi.org/10.1111/crj.13099
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38514
dc.identifier.volume14en_US
dc.identifier.wosWOS:000494264100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYormaz, Burcu
dc.institutionauthorCebeci, Hakan
dc.institutionauthorYılmaz, Farise
dc.institutionauthorSüerdem, Mecit
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofCLINICAL RESPIRATORY JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbone densitometeren_US
dc.subjectCOPDen_US
dc.subjectemphysemaen_US
dc.subjectosteoporosisen_US
dc.titleBone mineral density in emphysema and chronic bronchitis phenotypes in hospitalized male chronic obstructive pulmonary disease patientsen_US
dc.typeArticleen_US

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