Relationship Between L-arginine/asymmetric Dimethylarginine, Homocysteine, Folic Acid, Vitamin B Levels, and Coronary Artery Ectasia

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dc.contributor.authorKoç, Fatih
dc.contributor.authorArdıç, İdris
dc.contributor.authorErdem, Sami
dc.contributor.authorKalay, Nihat
dc.contributor.authorÖzbek, Kerem
dc.contributor.authorYarlıoğlueş, Mikail
dc.contributor.authorCeyhan, Köksal
dc.contributor.authorÇelik, Ataç
dc.contributor.authorKadi, Hasan
dc.contributor.authorTaner, Alpaslan
dc.contributor.authorŞahin, Şemsettin
dc.contributor.authorÖnalan, Orhan
dc.contributor.authorKaya, Mehmet Güngör
dc.date.accessioned2020-03-26T18:04:54Z
dc.date.available2020-03-26T18:04:54Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries. The ratio of L-arginine/asymmetric dimethylarginine (ADMA) and homocysteine are important factors for endothelial function. In this study, we investigate the ratio of L-arginine/ADMA, homocysteine, and folic acid/vitamin B levels in patients with CAE. Methods Forty patients diagnosed with CAE using coronary angiography were included in the study (24 male; mean age, 56 +/- 11 years). The control group consisted of 30 patients who had normal coronary arteries as determined by coronary angiography (11 male; mean age, 54 +/- 8 years). The ratio of L-arginine/ADMA and plasma homocysteine was measured using high-performance liquid chromatography. Results The L-arginine/ADMA ratio and L-arginine levels were significantly lower in the CAE group compared with the control group (110 +/- 27 vs. 149 +/- 77, P = 0.02 and 157 +/- 32 mu mol/l vs. 187 +/- 59 mu mol/l, P = 0.02, respectively). Plasma ADMA levels were similar in the two groups. Patients with CAE had higher plasma homocysteine levels (P = 0.01). Plasma folic acid, vitamin B6, and vitamin B12 levels were similar between the two groups. Conclusion This study shows that patients with CAE have a lower L-arginine/ADMA ratio and higher plasma homocysteine levels. These results show a potential relationship between endothelial dysfunction and CAE.en_US
dc.identifier.citationKoç, F., Ardıç, İ., Erdem, S., Kalay, N., Özbek, K., Yarlıoğlueş, M., Ceyhan, K., Çelik, A., Kadi, H., Taner, A., Şahin, Ş., Önalan, O., Kaya, M. G., (2010). Relationship Between L-arginine/asymmetric Dimethylarginine, Homocysteine, Folic Acid, Vitamin B Levels, and Coronary Artery Ectasia. Coronary Artery Disease, 21(8), 445-449. Doi: 10.1097/MCA.0b013e32833fd22b
dc.identifier.doi10.1097/MCA.0b013e32833fd22ben_US
dc.identifier.endpage449en_US
dc.identifier.issn0954-6928en_US
dc.identifier.issue8en_US
dc.identifier.pmid20861735en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MCA.0b013e32833fd22b
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25210
dc.identifier.volume21en_US
dc.identifier.wosWOS:000284150800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdem, Sami
dc.institutionauthorTaner, Alpaslan
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectasymmetric dimethylarginineen_US
dc.subjectcoronary artery ectasiaen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectfolic aciden_US
dc.subjecthomocysteineen_US
dc.subjectL-arginineen_US
dc.subjectvitamin B6en_US
dc.subjectvitamin B12en_US
dc.titleRelationship Between L-arginine/asymmetric Dimethylarginine, Homocysteine, Folic Acid, Vitamin B Levels, and Coronary Artery Ectasiaen_US
dc.typeArticleen_US

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