Effects of Phototherapy on the Growth Plate in Newborn Rats

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorPirgon, Özgür
dc.contributor.authorKurtoğlu, Selim
dc.contributor.authorTavlı, Lema
dc.contributor.authorEsen, H. Hasan
dc.contributor.authorKöylü, Öznur
dc.contributor.authorErkul, İbrahim
dc.date.accessioned2020-03-26T17:03:27Z
dc.date.available2020-03-26T17:03:27Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of the present study was to evaluate the effect of phototherapy and oxidative stress on the growth plate of newborn rats. Forty newborn Sprague-Dawley rats were randomized into a phototherapy group and a control group. Twenty of the rats received phototherapy for 7 days. All zones of the growth plate were assessed with quantitative histomorphometric analysis. Individual zonal lengths were measured for the reserve zone (RZ), the proliferative zone (PZ), the hypertropbic zone (HZ), ossifying cartilage (OC), and total zone (TZ) of the growth plate. Levels of plasma malondialdehyde (MDA), an index of oxidative stress, were also evaluated. Compared with zonal lengths on day 7 after phototherapy between the two groups, the phototherapy group had significantly lower values than those of controls for RZ (5.13 +/- 0.36 vs. 6.4 +/- 0.85 mm X 10(-2); P < 0.001), PZ (20.6 +/- 3.0 vs. 29.25 +/- 1.68 mm X 10(-2); p < 0.001), HZ (15.4 +/- 1.44 vs. 20.87 +/- 1.12 mm X 10(-1); P < 0.001), OC (47.08 +/- 4.25 vs. 62.06 +/- 3.7 mm X 10(-2); p < 0.001), and TZ (88.15 +/- 6.56 vs. 118.48 +/- 4.50 mm X 10(-2); p < 0.001). Plasma MDA levels were correlated with the size of the PZ in the phototherapy group (r = -0.53, P = 0.01). In a multivariate regression model for all rats, being in the phototherapy group was the best predictor of the size of the TZ (beta = -0.94, P < 0.001), with the total variance explained being 88%. These results suggest that in newborn rats, receiving phototherapy is associated with early impairment of growth plate structure, and oxidative stress may be the main risk factor for growth plate injury.en_US
dc.identifier.citationAtabek, M. E., Pirgon, Ö., Kurtoğlu, S., Tavlı, L., Esen, H. H., Köylü, Ö., Erkul, İ., (2006). Effects of Phototherapy on the Growth Plate in Newborn Rats. Journal of Pediatric Orthopaedics, 26(1), 144-147. Doi: 10.1097/01.bpo.0000191556.11326.66
dc.identifier.doi10.1097/01.bpo.0000191556.11326.66en_US
dc.identifier.endpage147en_US
dc.identifier.issn0271-6798en_US
dc.identifier.issue1en_US
dc.identifier.pmid16439921en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage144en_US
dc.identifier.urihttps://dx.doi.org/10.1097/01.bpo.0000191556.11326.66
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20465
dc.identifier.volume26en_US
dc.identifier.wosWOS:000234348700030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAtabek, Mehmet Emre
dc.institutionauthorPirgon, Özgür
dc.institutionauthorTavlı, Lema
dc.institutionauthorEsen, H. Hasan
dc.institutionauthorKöylü, Öznur
dc.institutionauthorErkul, İbrahim
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Orthopaedicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectphototherapyen_US
dc.subjectnewborn ratsen_US
dc.subjectgrowth plateen_US
dc.subjectoxidative stressen_US
dc.titleEffects of Phototherapy on the Growth Plate in Newborn Ratsen_US
dc.typeArticleen_US

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