Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
FUNPEC-EDITORA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We investigated a possible association between aggrecan gene polymorphism and lumbar degenerative disc disease in Turkish patients. One hundred 20-30-year-old patients with or without low back pain were selected for the study. Lumbar magnetic resonance imaging was performed on all patients. The patient group had low back pain clinically and degenerative disc disease radiographically. The control group included patients with and without low back pain: all were negative radiographically for degenerative disc disease. Genomic DNA was extracted from all participants. A PCR assay were used to evaluate variable number of tandem repeat polymorphism of aggrecan gene alleles to determine if there was any correlation with degenerative disc disease. Significant associations were found between short repeated alleles of the aggrecan gene and severe disc degeneration. A significant association was also found between short repeated alleles of the aggrecan gene and multilevel disc herniation as well as extrusion and sequestration types of disc herniation. In Turkish population, short repeated alleles of the aggrecan gene are associated with increased disc degeneration and disc herniation.
Açıklama
Anahtar Kelimeler
Aggrecan gene, Disc degeneration, Polymorphism, Lumbar
Kaynak
GENETICS AND MOLECULAR RESEARCH
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
10
Sayı
3
