Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients

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dc.contributor.authorEser, O.
dc.contributor.authorEser, B.
dc.contributor.authorCosar, M.
dc.contributor.authorErdogan, M. O.
dc.contributor.authorAslan, A.
dc.contributor.authorYildiz, H.
dc.contributor.authorSolak, M.
dc.date.accessioned2020-03-26T18:16:08Z
dc.date.available2020-03-26T18:16:08Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe investigated a possible association between aggrecan gene polymorphism and lumbar degenerative disc disease in Turkish patients. One hundred 20-30-year-old patients with or without low back pain were selected for the study. Lumbar magnetic resonance imaging was performed on all patients. The patient group had low back pain clinically and degenerative disc disease radiographically. The control group included patients with and without low back pain: all were negative radiographically for degenerative disc disease. Genomic DNA was extracted from all participants. A PCR assay were used to evaluate variable number of tandem repeat polymorphism of aggrecan gene alleles to determine if there was any correlation with degenerative disc disease. Significant associations were found between short repeated alleles of the aggrecan gene and severe disc degeneration. A significant association was also found between short repeated alleles of the aggrecan gene and multilevel disc herniation as well as extrusion and sequestration types of disc herniation. In Turkish population, short repeated alleles of the aggrecan gene are associated with increased disc degeneration and disc herniation.en_US
dc.description.sponsorshipKocatepe University Scientific Research CommitteeAfyon Kocatepe University [051.TIP.44]en_US
dc.description.sponsorshipThe authors thank Murat Acar and Bumin Degirmenci for help with visual assessment of magnetic resonance images. Research supported by the Kocatepe University Scientific Research Committee (Project #051.TIP.44).en_US
dc.identifier.doi10.4238/vol10-3gmr1222en_US
dc.identifier.endpage1930en_US
dc.identifier.issn1676-5680en_US
dc.identifier.issue3en_US
dc.identifier.pmid21948754en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1923en_US
dc.identifier.urihttps://dx.doi.org/10.4238/vol10-3gmr1222
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26816
dc.identifier.volume10en_US
dc.identifier.wosWOS:000295823500062en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFUNPEC-EDITORAen_US
dc.relation.ispartofGENETICS AND MOLECULAR RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAggrecan geneen_US
dc.subjectDisc degenerationen_US
dc.subjectPolymorphismen_US
dc.subjectLumbaren_US
dc.titleShort aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patientsen_US
dc.typeArticleen_US

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