Effect of Lipoprotein Apheresis on Oxidative Stress and Antioxidant Status in Familial Hypercholesterolemic Patients
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wichtig Editore
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Extracorporeal low-density lipoprotein (LDL) apheresis is an established and highly effective therapy for the patients with familial hypercholesterolemia (FH) not adequately responding to diet and drug therapy alone. This study was designed to measure the effect of lipid apheresis on oxidant and antioxidant status in a patient with FH. The levels of plasma lipid peroxidation were determined as thiobarbituric acid-reactive substances. The activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were established in one subject with FH before and after lipid apheresis. The pre- and post lipid apheresis procedures witness a significant decrease in oxidative stress (p<0.05) but the erythrocyte levels of CAT SOD and GPx were unchanged.
Açıklama
Anahtar Kelimeler
Familial Hypercholesterolemia, Lipid Apheresis, Oxidative Stress, Antioxidants
Kaynak
International Journal of Artificial Organs
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
26
Sayı
11
Künye
Kurtoğlu, E., Uğur, A., Gönen, M. S., Kısakol, G., (2003). Effect of Lipoprotein Apheresis on Oxidative Stress and Antioxidant Status in Familial Hypercholesterolemic Patients. International Journal of Artificial Organs, 26(11), 1039-1043.
