Serum D-Lactate Levels as a Predictor of Intestinal Ischemia-Reperfusion Injury

Basit Öğe Kaydı
dc.contributor.authorGünel, E.
dc.contributor.authorÇağlayan, O.
dc.contributor.authorÇağlayan, F.
dc.date.accessioned2020-03-26T16:26:18Z
dc.date.available2020-03-26T16:26:18Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCurrently, no serum marker has proved helpful in diagnosing intestinal ischemia and reperfusion (I/R) injury. An experimental study was conducted to determine the value of serum D-lactate in detecting intestinal I/R injury. Thirty New Zealand White rabbits were divided into three groups of 10 animals each: sham-operation controls (S); I/R; and I/R plus mannitol treatment (M). Serum samples were obtained before operation (T-0), at the end of the ischemic period (T-1), after the first 30 min of reperfusion (T-2), and at the end of the reperfusion period (T-3) In Group S, mean D-lactate levels for T-0, T-1, and T-2 were 0 mu g/dl, while T-3 was 5.8 +/- 4.7 mu g/dl. Before the operation (T-0), Serum mean D-lactate levels were 0 mu g/dl in all groups (S, I/R, M). Levels increased after 1 h of ischemia (T-1) in groups I/R (83.5 +/- 25.6 mu g/dl) and M (89.8 +/- 19.9 mu g/dl), but not in group S (0 mu g/dl). The mean T-2 level in group I/R (231.6 +/- 78.6 mu g/dl) was statistically higher than in group M (140.1 +/- 53.5 mu g/dl) (P = 0.007). At the end of the reperfusion period, the mean T-3 level in group I/R (698.4 +/- 360.4 mu g/dl) was significantly higher than in group M (158.7 +/- 61.4 mu g/dl)(P = 0.000). In group I/R, mean D-lactate levels changed significantly at each time point (T-1 vs T-2, P = 0.001; T-2 VS T-3, P = 0.004). However, in group M the increase from T-1 to T-2 was significant (P = 0.012), but that from T-2 to T-3 was not (P = 0.293). As a result, the mean T-3 level was significantly higher than the T-2 level in group I/R (P = 0.004), but not in group M. This study confirmed a significance rise in D-lactate levels in animals with I/R injury compared to sham-operated and I/R injury plus M treatment. We suggest that serum D-lactate levels could be a useful marker of intestinal I/R injury before laparatomy.en_US
dc.identifier.citationGünel, E., Çağlayan, O., Çağlayan, F., (1998). Serum D-Lactate Levels as a Predictor of Intestinal Ischemia-Reperfusion Injury. Pediatric Surgery International, 14(1998), 59-61. DOI:10.1007/s003830050436
dc.identifier.doi10.1007/s003830050436en_US
dc.identifier.endpage61en_US
dc.identifier.issn0179-0358en_US
dc.identifier.pmid9880698en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s003830050436
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16791
dc.identifier.volume14en_US
dc.identifier.wosWOS:000077362000016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünel, E.
dc.institutionauthorÇağlayan, O.
dc.institutionauthorÇağlayan, F.
dc.language.isoenen_US
dc.publisherSPRINGER VERLAGen_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectSerum D-Lactateen_US
dc.subjectMannitolen_US
dc.titleSerum D-Lactate Levels as a Predictor of Intestinal Ischemia-Reperfusion Injuryen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
6791.pdf
Boyut:
69.28 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Çocuk Cerrahisi/Makale Koleksiyonu