TNF-Alpha and IL-6 as biomarkers of impaired lung functions in dimethylacetamide exposure

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dc.contributor.authorTutkun, Lütfiye
dc.contributor.authorİritaş, Servet Birgin
dc.contributor.authorDeniz, Serdar
dc.contributor.authorÖztan, Özgür
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorÜnlü, Ali
dc.contributor.authorTürksoy, Vugar Ali
dc.contributor.authorÇetintepe, Sultan Pınar
dc.date.accessioned2020-03-26T20:19:37Z
dc.date.available2020-03-26T20:19:37Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc exposed people. Methods: 101 non-exposed control subjects (Group 1) and 109 DMAc-exposed workers from the polyvinyl chloride (PVC) industry were included in the study. In the next step, the exposed group was divided into two groups according to the level of exposure (Group 2 and 3). DMAc, TNF-alpha, IL-6, creatinine, ALT, AST, GFR and standard spirometry measurements were carried out in all subjects. Results: When compared to the control group, TNF-alpha and IL-6 levels were significantly high compatible with the increase of DMAc levels, in the exposed groups. Urinary DMAc Levels were 0.06 mg/L in the control group. This level is significantly low when compared to exposed and severely exposed group (2.43 mg/L and 3.17 mg/L). TNF-alpha levels were 56.86 pg/mL, 145.52 pg/mL and 230.52 pg/mL in control, exposed and severely exposed groups. IL-6 levels were found to be 38.08 pg/mL, 89.19 pg/mL and 116 pg/mL for control, exposed and severely exposed groups, respectively. Similarly, the FEV1/FVC ratio decreased especially in the severely exposed group (p 0.001). Conclusions: In our study, results have revealed that TNF-and IL-6 levels are promising biomarkers in the early diagnosis of lung function impairment in inhalational DMAc exposure.en_US
dc.identifier.citationTutkun, L., İritaş, S. B., Deniz, S., Öztan, Ö., Abuşoğlu, S., Ünlü, A., Türksoy, V. A., Çetintepe, S. P. (2019). TNF-Alpha and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure. Journal of Medical Biochemistry, 38(3)- 276-283.
dc.identifier.doi10.2478/jomb-2018-0040en_US
dc.identifier.endpage283en_US
dc.identifier.issn1452-8258en_US
dc.identifier.issn1452-8266en_US
dc.identifier.issue3en_US
dc.identifier.pmid31156337en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage276en_US
dc.identifier.urihttps://dx.doi.org/10.2478/jomb-2018-0040
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38342
dc.identifier.volume38en_US
dc.identifier.wosWOS:000468363100004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAbuşoğlu, Sedat
dc.institutionauthorÜnlü, Ali
dc.language.isoenen_US
dc.publisherSCIENDOen_US
dc.relation.ispartofJOURNAL OF MEDICAL BIOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdimethylacetamide (DMAc)en_US
dc.subjecttumour necrosis factor-alpha (TNF-alpha)en_US
dc.subjectinterleukin-6 (IL-6)en_US
dc.subjectpulmonary capacitiesen_US
dc.subjecttoxic inhalationen_US
dc.titleTNF-Alpha and IL-6 as biomarkers of impaired lung functions in dimethylacetamide exposureen_US
dc.typeArticleen_US

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