Serum Intestinal Fatty Acid Binding Protein and Phosphate Levels in the Diagnosis of Acute Intestinal Ischemia: An Experimental Study in Rabbits

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dc.contributor.authorDündar, Zerrin Defne
dc.contributor.authorCander, Başar
dc.contributor.authorGül, Mehmet
dc.contributor.authorUçar Karabulut, Keziban
dc.contributor.authorKoçak, Sedat
dc.contributor.authorGirişgin, Sadık
dc.contributor.authorMehmetoğlu, İdris
dc.contributor.authorToy, Hatice
dc.date.accessioned2020-03-26T18:31:18Z
dc.date.available2020-03-26T18:31:18Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Acute intestinal ischemia is a serious clinical disorder with mesenteric infarction, which has high mortality. It is important to establish a biochemical marker for the early diagnosis of acute intestinal ischemia. Objectives: The aim of this experimental study was to assess the changes in the serum levels of intestinal fatty acid binding protein (IFABP) and phosphate by time using the acute intestinal ischemia model in rabbits. Methods: In this study, 21 New Zealand rabbits were randomly divided into three groups. Blood samples were obtained at 0, 1, 3, and 6 h in the control group. Blood samples were obtained at 0, 1, 3, and 6 h in the sham group after simple laparotomy. Blood samples were obtained at the same hours in the ischemia group after simple laparotomy and ligation of the superior mesenteric artery. Results: There was no significant difference between the control, the sham, and the ischemia groups in terms of serum IFABP levels at any time (p > 0.05). Serum phosphate levels significantly increased in the ischemia group (p < 0.001). Studies on IFABP have begun emerging in the literature, and there is no standard approach for the technique to measure the IFABP level. No studies on IFABP were found in the literature on rabbits. Conclusion: Based on our results, the role that IFABP levels play in the diagnosis of acute intestinal ischemia is unclear at this time. Serum phosphate levels continued to rise as the duration of ischemia was prolonged. These findings support the suggestion that serum phosphate levels are valuable for the diagnosis of acute intestinal ischemia.en_US
dc.identifier.citationDündar, Z. D., Cander, B., Gül, M., Uçar Karabulut, K., Koçak, S., Girişgin, S., Mehmetoğlu, İ., Toy, H., (2012). Serum Intestinal Fatty Acid Binding Protein and Phosphate Levels in the Diagnosis of Acute Intestinal Ischemia: An Experimental Study in Rabbits. Journal of Emergency Medicine, 42(6), 741-747.
dc.identifier.doi10.1016/j.jemermed.2011.05.051en_US
dc.identifier.endpage747en_US
dc.identifier.issn0736-4679en_US
dc.identifier.issue6en_US
dc.identifier.pmid21871766en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage741en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jemermed.2011.05.051
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28400
dc.identifier.volume42en_US
dc.identifier.wosWOS:000305591000022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorToy, Hatice
dc.institutionauthorMehmetoğlu, İdris
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofJournal of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIFABPen_US
dc.subjectintestinal ischemiaen_US
dc.subjectphosphateen_US
dc.subjectrabbiten_US
dc.subjectabdominal painen_US
dc.titleSerum Intestinal Fatty Acid Binding Protein and Phosphate Levels in the Diagnosis of Acute Intestinal Ischemia: An Experimental Study in Rabbitsen_US
dc.typeArticleen_US

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