The role of zinc in the endocrine system

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dc.contributor.authorBaltaci, Abdulkerim Kasim.
dc.contributor.authorMogulkoc, Rasim.
dc.contributor.authorBaltaci, Saltuk Bugra.
dc.date.accessioned2020-03-26T20:19:34Z
dc.date.available2020-03-26T20:19:34Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractZinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Therefore, growth impairment, hypogonadism, and some endocrine diseases are associated with the deficiency of zinc. These effects of zinc are considered versatile. Zinc increases the synthesis of the growth hormone and its number of receptors; thus, it is an important mediator in the binding of this hormone to its receptor. Found in a large quantity in the pancreas tissue, zinc has a part in the regulation of the effect of insulin. Zinc is involved to much more thyroid hormone metabolism such as hormone synthesis, receptor activity, conversion of T4 to T3, and production of carrier proteins. The low levels of zinc and high levels of leptin in obese individuals point to a critical relationship between zinc and leptin. Zinc is related to enzyme activity to melatonin synthesis. Melatonin has regulatory activity for zinc absorption from gastrointestinal system. Zinc particularly affects the conversion of testosterone to dihydrotestosterone, as 5 alpha-reductase that is involved in this conversion is a zinc-dependent enzyme. In consideration of these relations, zinc is accepted to play critical roles in the endocrine system. The aim of the current review is to draw attention to the effects of zinc on the endocrine system.en_US
dc.identifier.citationBaltaci, A. K., Mogulkoc, R., Baltaci, S. B. (2019). The Role of Zinc in the Endocrine System. Pakistan Journal of Pharmaceutical Sciences, 32(1), 231-239.
dc.identifier.endpage239en_US
dc.identifier.issn1011-601Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid30772815en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38324
dc.identifier.volume32en_US
dc.identifier.wosWOS:000460846900033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaltaci, Abdulkerim Kasim.
dc.institutionauthorMogulkoc, Rasim.
dc.institutionauthorBaltaci, Saltuk Bugra.
dc.language.isoenen_US
dc.publisherUNIV KARACHIen_US
dc.relation.ispartofPAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCESen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectZincen_US
dc.subjectendocrine systemen_US
dc.subjecthormonesen_US
dc.titleThe role of zinc in the endocrine systemen_US
dc.typeArticleen_US

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