Anthropometric Indexes, Insulin Resistance, and Serum Leptin and Lipid Levels in Women With Cryptogenic Epilepsy Receiving Topiramate Treatment
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We aimed to investigate the effects of topiramate monotherapy on anthropometric indexes, insulin resistance, and serum leptin and lipid levels in 33 premenopausal women (mean age +/- standard deviation: 26.7 +/- 7.1 years) with cryptogenic epilepsy. Body mass index (BMI), waist circumference and serum leptin, insulin and lipid levels were measured at baseline and at 6 months after initiation of topiramate. We found reductions in BMI (p < 0.001), waist circumference (p < 0.001) and serum high-density lipoprotein (HDL) cholesterol levels (p = 0.011). We also found significant improvements in insulin resistance (p = 0.023), but not in serum leptin levels (p = 0.45). Our results suggest that topiramate treatment in women with epilepsy is associated with reduced BMI and waist circumference and improvement in insulin resistance; however, according to our data, topiramate treatment is also associated with lower HDL cholesterol levels, which may substantially increase vascular disease.
Açıklama
Anahtar Kelimeler
Body mass index, HDL cholesterol, Insulin resistance, Leptin topiramate, Waist circumference
Kaynak
Journal of Clinical Neuroscience
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
17
Sayı
Künye
Genç, B. O., Doğan, E. A., Doğan, U., Genç, E., (2010). Anthropometric Indexes, Insulin Resistance, and Serum Leptin and Lipid Levels in Women With Cryptogenic Epilepsy Receiving Topiramate Treatment. Journal of Clinical Neuroscience, (17), 1256-1259. Doi: 10.1016/j.jocn.2010.01.045
