Anthropometric Indexes, Insulin Resistance, and Serum Leptin and Lipid Levels in Women With Cryptogenic Epilepsy Receiving Topiramate Treatment

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dc.contributor.authorGenç, Bülent Oğuz
dc.contributor.authorDoğan, Ebru Apaydın
dc.contributor.authorDoğan, Umuttan
dc.contributor.authorGenç, Emine
dc.date.accessioned2020-03-26T17:47:05Z
dc.date.available2020-03-26T17:47:05Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe aimed to investigate the effects of topiramate monotherapy on anthropometric indexes, insulin resistance, and serum leptin and lipid levels in 33 premenopausal women (mean age +/- standard deviation: 26.7 +/- 7.1 years) with cryptogenic epilepsy. Body mass index (BMI), waist circumference and serum leptin, insulin and lipid levels were measured at baseline and at 6 months after initiation of topiramate. We found reductions in BMI (p < 0.001), waist circumference (p < 0.001) and serum high-density lipoprotein (HDL) cholesterol levels (p = 0.011). We also found significant improvements in insulin resistance (p = 0.023), but not in serum leptin levels (p = 0.45). Our results suggest that topiramate treatment in women with epilepsy is associated with reduced BMI and waist circumference and improvement in insulin resistance; however, according to our data, topiramate treatment is also associated with lower HDL cholesterol levels, which may substantially increase vascular disease.en_US
dc.identifier.citationGenç, B. O., Doğan, E. A., Doğan, U., Genç, E., (2010). Anthropometric Indexes, Insulin Resistance, and Serum Leptin and Lipid Levels in Women With Cryptogenic Epilepsy Receiving Topiramate Treatment. Journal of Clinical Neuroscience, (17), 1256-1259. Doi: 10.1016/j.jocn.2010.01.045
dc.identifier.doi10.1016/j.jocn.2010.01.045en_US
dc.identifier.endpage1259en_US
dc.identifier.issn0967-5868en_US
dc.identifier.issn1532-2653en_US
dc.identifier.pmid20598547en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1256en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jocn.2010.01.045
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24620
dc.identifier.volume17en_US
dc.identifier.wosWOS:000281499900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGenç, Bülent Oğuz
dc.institutionauthorDoğan, Ebru Apaydın
dc.institutionauthorDoğan, Umuttan
dc.institutionauthorGenç, Emine
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBody mass indexen_US
dc.subjectHDL cholesterolen_US
dc.subjectInsulin resistanceen_US
dc.subjectLeptin topiramateen_US
dc.subjectWaist circumferenceen_US
dc.titleAnthropometric Indexes, Insulin Resistance, and Serum Leptin and Lipid Levels in Women With Cryptogenic Epilepsy Receiving Topiramate Treatmenten_US
dc.typeArticleen_US

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