Neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and mean platelet volume as systemic inflammatory markers in different states of bipolar disorder

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dc.contributor.authorInanli, Ikbal
dc.contributor.authorAydin, Memduha
dc.contributor.authorCaliskan, Ali Metehan
dc.contributor.authorEren, Ibrahim
dc.date.accessioned2020-03-26T20:15:24Z
dc.date.available2020-03-26T20:15:24Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Currently, increasing evidence supports the hypothesis that alterations in the immune-inflammatory system are critical for the pathophysiology of bipolar disorder (BD). Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and mean platelet volume (MPV) have recently been investigated as inexpensive and simple inflammatory markers. Aims: The aim of this study is to compare NLR, PLR, MLR, and MPV in depressive, manic, and euthymic patients with BD and healthy controls, and to evaluate whether values of NLR, PLR, MLR, and MPV are possible state or trait biomarkers in BD. Methods: This retrospective study was conducted with 341 patients with BD (100 patients in a depressive state, 141 patients in a manic state, and 100 patients in a euthymic state) and 114 healthy controls. Results: We found that patients with BD in manic states had higher levels of MPV, NLR, and MLR, and patients with BD in depressive states had higher levels of MPV than the controls. Moreover, MPV predicted all states of BD, while NLR and MLR predicted the manic state of BD. Conclusions: NLR, MLR, and MPV obtained from simple and inexpensive blood tests were significantly higher in patients with BD than in healthy controls, which each imply low-grade inflammation. MPV may serve as a possible trait biomarker of BD, while NLR and MLR may both serve as possible state biomarkers of the manic state.en_US
dc.identifier.citationInanli, I., Aydin, M., Çaliskan, A. M., Eren, I. (2019). Neutrophil/Lymphocyte Ratio, Monocyte/Lymphocyte Ratio, And Mean Platelet Volume As Systemic İnflammatory Markers İn Different States Of Bipolar Disorder. Nordic Journal Of Psychiatry, 73,(6), 372-379.
dc.identifier.doi10.1080/08039488.2019.1640789en_US
dc.identifier.endpage379en_US
dc.identifier.issn0803-9488en_US
dc.identifier.issn1502-4725en_US
dc.identifier.issue6en_US
dc.identifier.pmid31304832en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage372en_US
dc.identifier.urihttps://dx.doi.org/10.1080/08039488.2019.1640789
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38028
dc.identifier.volume73en_US
dc.identifier.wosWOS:000476287600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAydin, Memduha
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofNORDIC JOURNAL OF PSYCHIATRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBipolar disorderen_US
dc.subjectneutrophilen_US
dc.subjectlymphocyte ratioen_US
dc.subjectplateleten_US
dc.subjectlymphocyte ratioen_US
dc.subjectmonocyteen_US
dc.subjectlymphocyte ratioen_US
dc.subjectmean platelet volumeen_US
dc.titleNeutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and mean platelet volume as systemic inflammatory markers in different states of bipolar disorderen_US
dc.typeArticleen_US

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