Effect of curcumin on bone healing: An experimental study in a rat model of femur fracture

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dc.contributor.authorSafali, Selim.
dc.contributor.authorAydin, Bahattin Kerem.
dc.contributor.authorNayman, Alaaddin.
dc.contributor.authorUgurluoglu, Ceyhan.
dc.date.accessioned2020-03-26T20:13:35Z
dc.date.available2020-03-26T20:13:35Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To determine the radiologic, histologic and biomechanical effects of curcumin on bone healing using a total rat femur fracture injury model. Materials and methods: Sixty four male Wistar-Albino rats weighing 170-210 g were used in this study. The animals were randomly divided into eight groups and 5 or 6 animals were placed in each cage. A transverse femur shaft fracture model used. The animals in study groups received oral curcumin at a dose of 200 mg/kg for 14 days or 28 days. Remaining animals received only saline solution by oral gavage for a period of 14 days and 28 days as control groups. After sacrification the left femurs used for radiological, histological and biomechanical evaluation. Results: The groups treated with curcumin showed no significant difference in terms of radiological, histological and biomechanical evaluations in 14 days groups. Also there was no significant difference between curcumin and control groups for 28 days according to radiological, histological and biomechanical tests. Conclusions: According to our results, curcumin has no positive effect on fracture healing not only histologically but also radiologically and biomechanically. Curcumin's antioxidant effect may be more noticeable with long term follow up investigation as it may have a positive effect in remodelling phase. Long term follow up designed studies may be planned to investigate its effect on remodelling phase of fracture healing. (C) 2019 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research OfficeSelcuk Universityen_US
dc.description.sponsorshipThis study was funded by Selcuk University Scientific Research Office.en_US
dc.identifier.citationSafali, S., Aydin, B. K., Nayman, A., Ugurluoglu, C. (2019). Effect of Curcumin on Bone Healing: An Experimental Study in a Rat Model of Femur Fracture. Injury, 50(11), 1915-1920.
dc.identifier.doi10.1016/j.injury.2019.09.002en_US
dc.identifier.endpage1920en_US
dc.identifier.issn0020-1383en_US
dc.identifier.issn1879-0267en_US
dc.identifier.issue11en_US
dc.identifier.pmid31506168en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1915en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.injury.2019.09.002
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37723
dc.identifier.volume50en_US
dc.identifier.wosWOS:000497290900017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSafali, Selim.
dc.institutionauthorAydin, Bahattin Kerem.
dc.institutionauthorNayman, Alaaddin.
dc.institutionauthorUgurluoglu, Ceyhan.
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofINJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJUREDen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRaten_US
dc.subjectFemuren_US
dc.subjectFracture healingen_US
dc.subjectCurcuminen_US
dc.titleEffect of curcumin on bone healing: An experimental study in a rat model of femur fractureen_US
dc.typeArticleen_US

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