The improvement of biocompatibility of adhesives: The effects of resveratrol on biocompatibility and dentin micro-tensile bond strengths of self-etch adhesives

dc.contributor.authorAtalayin, Cigdem
dc.contributor.authorTezel, Huseyin
dc.contributor.authorErgucu, Zeynep
dc.contributor.authorUnlu, Nimet
dc.contributor.authorArmagan, Guliz
dc.contributor.authorDagci, Taner
dc.contributor.authorKose, Timur
dc.date.accessioned2020-03-26T20:19:30Z
dc.date.available2020-03-26T20:19:30Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractObjectiveThe aim of this in vitro study is to evaluate the effects of resveratrol (RES) addition on the cytotoxicity and microtensile bond strength (mu TBS) of different adhesives.Materials and methodsFive self-etching adhesives (G-aenial Bond-GC, Optibond All in One-Kerr, Gluma Self Etch-Kulzer, Clearfil S-3 Bond-Kuraray, and Nova Compo-B Plus-Imicryl) were tested. They were applied to L-929 cell culture by the extract method. In the test groups, 0.5 mu M RES (Sigma-Aldrich) was added into the medium. Cell viability was assessed by MTT assay after 24h. Human extracted third molars were used for mu TBS test (n=7). The adhesives with or without 0.5 mu M RES addition were applied on dentin surfaces. A composite build-up was constructed. Then, the specimens were sectioned into multiple beams with the non-trimming version of the microtensile test and subjected to microtensile forces. Statistical analysis was performed using ANOVA and post hoc Tukey test (p?0.05).ResultsThe extracts of all adhesives decreased the cell viability. However, RES addition increased the cell viability in all groups (p?0.05). RES addition did not cause any decrease in mu TBS values of the adhesives compared to baseline. Optibond All in One showed the highest mu TBS after RES addition. It was followed by Clerafil S-3 Bond and Nova Compo-B Plus. No difference was determined between the Optibond All in One and Clearfil S-3 Bond. There was difference between Optibond All in One and Nova Compo-B Plus (p?0.05).ConclusionRES addition may improve the biocompatibility without causing negative influence on mu TBS of the adhesives.Clinical relevanceRES addition has clinical applicable potential to overcome the adverse biocompatibility of adhesives.en_US
dc.identifier.citationAtalayin, C., Tezel, H., Ergucu, Z., Unlu, N., Armagan, G., Dagci, T., Kose, T.(2019). The Improvement of Biocompatibility of Adhesives: The Effects of Resveratrol on Biocompatibility and Dentin Micro-tensile Bond Strengths of Self-Etch Adhesives. Clinical Oral Investigation, 23,(8), 3213-3218.
dc.identifier.doi10.1007/s00784-018-2745-yen_US
dc.identifier.endpage3218en_US
dc.identifier.issn1432-6981en_US
dc.identifier.issn1436-3771en_US
dc.identifier.issue8en_US
dc.identifier.pmid30415440en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3213en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00784-018-2745-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38296
dc.identifier.volume23en_US
dc.identifier.wosWOS:000474396700008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUnlu, Nimet
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofCLINICAL ORAL INVESTIGATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdhesiveen_US
dc.subjectAntioxidanten_US
dc.subjectCell viabilityen_US
dc.subjectMicrotensile bond strengthen_US
dc.subjectResveratrolen_US
dc.titleThe improvement of biocompatibility of adhesives: The effects of resveratrol on biocompatibility and dentin micro-tensile bond strengths of self-etch adhesivesen_US
dc.typeArticleen_US

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