In Vivo Modulation of the Expressions of Fas and CD25 by Intravenous Immunoglobulin in Common Variable Immunodeficiency

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dc.contributor.authorArtaç, Hasibe
dc.contributor.authorKara, Reyhan
dc.contributor.authorReisli, İsmail
dc.date.accessioned2020-03-26T17:49:09Z
dc.date.available2020-03-26T17:49:09Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAlthough the presence of physiologic anti-CD95 (Fas, APO-1) autoantibodies in intravenous immunoglobulin (IVIG) preparations is known, the effects of these antibodies in patients with common variable immunodeficiency are unclear (CVID). The aim of the study was to assess the effects of IVIG in Fas expression, activation markers and the subsets of T cells in patients with CVID. We studied 15 cases with CVID and 10 healthy controls with no signs of immunodeficiency. The Fas expression of T cells, activation markers (CD25, CD69 and HLA-DR) and T-cell subsets were analyzed by four-color flow cytometry. We found that the Fas expression of CD3(+) T cells in patients was significantly higher than in controls. In addition, there was a significant increase in the Fas expression of CD3(+) T cells and CD4(+) T cells, and the CD25 expression of CD3(+) and CD4(+) T cells after IVIG supplementation (P < 0.05). The CD69 and HLA-DR expressions of T cells and CD8(+) T cells were not affected by IVIG infusion. Our observation showed that IVIG replacement causes an increase in the Fas and CD25 expressions in patients with CVID. These data suggest that the Fas protein may have an important role in the effects of IVIG for the control of autoimmunity in patients with CVID, as well as in the generation of autoimmune disease.en_US
dc.identifier.citationArtaç, H., Kara, R., Reisli, İ., (2010). In Vivo Modulation of the Expressions of Fas and CD25 by Intravenous Immunoglobulin in Common Variable Immunodeficiency. Clinical and Experimental Medicine, (10), 27-31. Doi: 10.1007/s10238-009-0061-1
dc.identifier.doi10.1007/s10238-009-0061-1en_US
dc.identifier.endpage31en_US
dc.identifier.issn1591-8890en_US
dc.identifier.issn1591-9528en_US
dc.identifier.pmid19730984en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10238-009-0061-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24998
dc.identifier.volume10en_US
dc.identifier.wosWOS:000273786700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArtaç, Hasibe
dc.institutionauthorKara, Reyhan
dc.institutionauthorReisli, İsmail
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofClinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIntravenous immunoglobulinen_US
dc.subjectFas (CD95)en_US
dc.subjectT cellsen_US
dc.subjectCD25en_US
dc.subjectCommon variable immunodeficiencyen_US
dc.titleIn Vivo Modulation of the Expressions of Fas and CD25 by Intravenous Immunoglobulin in Common Variable Immunodeficiencyen_US
dc.typeArticleen_US

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