Is Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an Experimental Stroke Model?

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dc.contributor.authorAltınay, Serdar
dc.contributor.authorÇabalar, Murat
dc.contributor.authorİşler, Cihan
dc.contributor.authorYıldırım, Funda
dc.contributor.authorÇelik, Duygu S.
dc.contributor.authorZengi, Oğuzhan
dc.contributor.authorTas, Abdurrahim
dc.date.accessioned2020-03-26T19:41:57Z
dc.date.available2020-03-26T19:41:57Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAIM: To investigate the neuroprotective effect of chronic curcumin supplementation on the rat forebrain prior to ischemia and reperfusion. MATERIAL and METHODS: Forebrain ischemia was induced by bilateral common carotid artery occlusion for 1/2 hour, followed by reperfusion for 72 hours. Older rats were divided into five groups: Group I received 300 mg/kg oral curcumin for 21 days before ischemia and 300 mg/kg intraperitoneal curcumin after ischemia; Group II received 300 mg/kg intraperitoneal curcumin after ischemia; Group III received 300 mg/kg oral curcumin for 21 days before ischemia; Group IV had only ischemia; Group V was the sham-operated group. The forebrain was rapidly dissected for biochemical parameter assessment and histopathological examination. RESULTS: In forebrain tissue, enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase were significantly higher in Group I than Groups II or III (p<0.05) while xanthine dehydrogenase and malondialdehyde enzyme activities and concentrations of interleukin-6 and TNF-alpha were significantly lower in Group I when compared to Groups II and III (p<0.05). A significant reduction in neurological score was observed after 24 and 72 hours in the curcumin-treated groups compared with the ischemic group. We also found a marked reduction in apoptotic index after 72 hours in the groups receiving curcumin. Significantly more TUNEL-positive cells were observed in the ischemic group compared to those treated with curcumin. CONCLUSION: We demonstrated the neuroprotective effect of chronic curcumin supplement on biochemical parameters, neurological scores and apoptosis following ischemia and reperfusion injury in rats.en_US
dc.description.sponsorshipMinistry of Health, Health Science University, Bagcilar Training and Research Hospital [2013/11]en_US
dc.description.sponsorshipThis work was funded by the Ministry of Health, Health Science University, Bagcilar Training and Research Hospital, Research Funding (Grant No. 2013/11).en_US
dc.identifier.citationAltınay S., Çabalar M., İşler C., Yıldırım F., Çelik D. S., Zengi O., Tas A. (2017). Is Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an Experimental Stroke Model?. TURKISH NEUROSURGERY, 27(4), 537-545.
dc.identifier.doi10.5137/1019-5149.JTN.17405-16.0en_US
dc.identifier.endpage545en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue4en_US
dc.identifier.pmid27593816en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage537en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.17405-16.0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35237
dc.identifier.volume27en_US
dc.identifier.wosWOS:000406170300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH NEUROSURGICAL SOCen_US
dc.relation.ispartofTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCurcuminen_US
dc.subjectIschemiaen_US
dc.subjectStrokeen_US
dc.subjectNeuroprotective effecten_US
dc.subjectOxidative stressen_US
dc.titleIs Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an Experimental Stroke Model?en_US
dc.typeArticleen_US

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