Investigation of some 3H-quinazolin-4-one derivatives in vitro antimicrobial effect and cytotoxicity on human gingival fibroblasts
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study is to synthesize and investigate antimicrobial and cytotoxic activity of 3 H-quinazolinone (1), and its derivatives, which are 3-(4-hydroxyphenyl)-3,4-dihydroquinazolin-4-one (2), 3-(3-hydroxyphenyl)-3,4-dihydroquinazolin-4-one (3), 3-(pyridin-3-ylmethy)-3,4-dihydroquinazolin-4-one (4) and derivatives of 2-methyl-3H-quinazolinone, which are 2-methyl-3-phenyl-3,4-dihydroquinazolin-4-one (6), 2-methyl-3(4-hydroxyphenyl)-3,4- dihydroquinazolin-4-one (7), 2-methyl-3(4-nitrophenyl)-3,4-dihydroquinazolin-4-one (8), compounds. Compounds 2 and 3 were synthesized newly. All compounds were characterized via infrared, H-1-NMR, C-13-NMR, elemental and mass spectral analysis. The compounds were screened for their antimicrobial activity in vitro against E. faecalis ATCC 29212, P. aeruginosa ATCC 27853, S. aureus ATCC 29213, E. Coli ATCC 25922 bacteria and compared with commercial antibiotics (Ampicillin and Gentamicin). The determination of the antimicrobial activity was done by using the broth microdilution methods. The antimicrobial test results indicated that the compounds (1, 4, 6, and 8) have MIC values against P. aeruginosa ATCC 27853 lower than ampicillin. But clear cytotoxic effects on proliferation of the gingival fibroblasts applications were observed in 1, 4, 6, and 8 when compared to the control group.
Açıklama
Anahtar Kelimeler
Antibacterial, Cytotoxicity, Gingival fibroblast, Quinazolinone
Kaynak
POLYCYCLIC AROMATIC COMPOUNDS
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
Sayı
Künye
Demirel, U. U., Yilmaz, A., Türkdağı, H., Öztürk, B., Arslan, U. (2019). Investigation of Some 3H-Quinazolin-4-One Derivatives in Vitro Antimicrobial Effect and Cytotoxicity on Human Gingival Fibroblasts. Polycyclic Aromatic Compounds, 2019, 1-8.
