Oxidative Stress and Anti-Oxidant Status in Diabetic Rat Liver: Effect of Plant Polyphenols

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dc.contributor.authorBelviranlı, Muaz
dc.contributor.authorGökbel, Hakkı
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBüyükbaş, Sadık
dc.date.accessioned2020-03-26T18:30:59Z
dc.date.available2020-03-26T18:30:59Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIncreased evidence in role of oxidative stress and grape seed extract (GSE) in diabetes and its complication led us to investigate the changes of oxidative stress and anti-oxidant defence in liver tissue of diabetic rats and possible effects of GSE. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Seven days after STZ injection four groups were formed: Control, GSE-supplemented control, diabetic and GSE-supplemented diabetic and GSE was given for 6 weeks. Malondialdehyde levels and xanthine oxidase activities were not different among the groups. However, nitric oxide (NO) levels were higher in diabetic and GSE supplemented groups compared with non-diabetic and non-supplemented groups, respectively. Total anti-oxidant activity (TAA) was lower in diabetic groups compared with their non-diabetic controls and it was not affected by GSE. In conclusion, GSE supplementation has limited protective effect in liver tissue of diabetic rats via affecting NO levels and was not affecting TAA.en_US
dc.identifier.citationBelviranlı, M., Gökbel, H., Okudan, N., Büyükbaş, S., (2012). Oxidative Stress and Anti-Oxidant Status in Diabetic Rat Liver: Effect of Plant Polyphenols. Archives of Physiology and Biochemistry, 118(5), 237-243. DOI: 10.3109/13813455.2012.702775
dc.identifier.doi10.3109/13813455.2012.702775en_US
dc.identifier.endpage243en_US
dc.identifier.issn1381-3455en_US
dc.identifier.issn1744-4160en_US
dc.identifier.issue5en_US
dc.identifier.pmid22803804en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://dx.doi.org/10.3109/13813455.2012.702775
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28282
dc.identifier.volume118en_US
dc.identifier.wosWOS:000311234800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBelviranlı, Muaz
dc.institutionauthorGökbel, Hakkı
dc.institutionauthorOkudan, Nilsel
dc.institutionauthorBüyükbaş, Sadık
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiabetes mellitusen_US
dc.subjectgrape seed extracten_US
dc.subjectlipid peroxidationen_US
dc.subjectnitric oxideen_US
dc.subjecttotal anti-oxidant activityen_US
dc.titleOxidative Stress and Anti-Oxidant Status in Diabetic Rat Liver: Effect of Plant Polyphenolsen_US
dc.typeArticleen_US

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