Treatment of Intestinal Reperfusion Injury Using Antioxidative Agents

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dc.contributor.authorGünel, Engin
dc.contributor.authorÇağlayan, Fatma
dc.contributor.authorÇağlayan, Osman
dc.contributor.authorDilsiz, Alaeddin
dc.contributor.authorDuman, Selçuk
dc.contributor.authorAktan, Murat
dc.date.accessioned2020-03-26T16:26:26Z
dc.date.available2020-03-26T16:26:26Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/Purpose: A number of antioxidants are present in human tissues, which comprise the secondary defence system against the oxygen-free radicals and oxidative stress. Therefore, this study was undertaken in an animal model to investigate the effects of antioxidants such as vitamin E, vitamin C, methyl prednisolone, and mannitol, on the treatment of intestinal reperfusion injury when given during ischemia. Methods: The study was performed on six groups of animals, each composed of six rabbits: Group I, mesenteric ischemia group; group R, ischemia-reperfusion group; group E, ischemia-reperfusion plus Vitamin E treatment; group C, ischemia-reperfusion plus vitamin C treatment; group CS, ischemia-reperfusion plus corticosteroid treatment; and Group M, ischemia-reperfusion plus mannitol treatment. Malondialdehyde (MDA) and glutathione (GSH) levels of the intestinal mucosa were assayed to reflect the free radical formation. Results: Mucosal injury scores in the M and C groups were significantly lower than the R group (P < .01 and P < .01, respectively), and in the E and CS groups, mucosal injury scores were not significantly different from R group. MDA levels in the M and C groups were significantly lower than the R group (P < .01 and P < .01, respectively). GSH levels in the E, C, and M groups, were significantly higher than R group (P < .01, P < .05, and P < .01, respectively). Conclusion: The results of this study showed that antioxidant drugs, such as vitamin C and mannitol, may play a role in attenuating reperfusion injury of the gut demonstrated by depression of tissue MDA levels and by elevation of tissue GSH levels.en_US
dc.identifier.citationGünel, E., Çağlayan, F., Çağlayan, O., Dilsiz, A., Duman, S., Aktan, M., (1998). Treatment of Intestinal Reperfusion Injury Using Antioxidative Agents. Journal of Pediatric Surgery, 33(10), 1536-1539. DOI: 10.1016/S0022-3468(98)90492-4
dc.identifier.doi10.1016/S0022-3468(98)90492-4en_US
dc.identifier.endpage1539en_US
dc.identifier.issn0022-3468en_US
dc.identifier.issue10en_US
dc.identifier.pmid9802808en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1536en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0022-3468(98)90492-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16818
dc.identifier.volume33en_US
dc.identifier.wosWOS:000076492500019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünel, Engin
dc.institutionauthorÇağlayan, Fatma
dc.institutionauthorÇağlayan, Osman
dc.institutionauthorDilsiz, Alaeddin
dc.institutionauthorDuman, Selçuk
dc.institutionauthorAktan, Murat
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSmall Intestineen_US
dc.subjectReperfusion Injuryen_US
dc.subjectAntioxidant Therapyen_US
dc.subjectVitamin Cen_US
dc.subjectVitamin Een_US
dc.subjectCorticosteroiden_US
dc.subjectMannitolen_US
dc.titleTreatment of Intestinal Reperfusion Injury Using Antioxidative Agentsen_US
dc.typeArticleen_US

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