Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia
Yükleniyor...
Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: The effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 µg, Escherichia coli 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg, subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p<0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.
Açıklama
Anahtar Kelimeler
IL-1, IL-10, Lipopolysaccharide, Tilmicosin, TNF
Kaynak
Journal of Animal and Veterinary Advances
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
8
Sayı
5
Künye
Uney, K., Er, A., Avcı, G., Bülbül, A., Elmas, M., Yazar, E., (2009). Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia. Journal of Animal and Veterinary Advances, 8(5), 1021-1024. Doi: 10.3923/javaa.2009.1021.1024
