Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia
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Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Abstract: The effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 µg, Escherichia coli 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg, subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p<0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.
Description
Keywords
IL-1, IL-10, Lipopolysaccharide, Tilmicosin, TNF
Journal or Series
Journal of Animal and Veterinary Advances
WoS Q Value
Q4
Scopus Q Value
N/A
Volume
8
Issue
5
Citation
Uney, K., Er, A., Avcı, G., Bülbül, A., Elmas, M., Yazar, E., (2009). Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia. Journal of Animal and Veterinary Advances, 8(5), 1021-1024. Doi: 10.3923/javaa.2009.1021.1024
