Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia

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dc.contributor.authorUney, Kamil
dc.contributor.authorEr, Ayşe
dc.contributor.authorAvcı, Gülcan
dc.contributor.authorBülbül, Aziz
dc.contributor.authorElmas, Muammer
dc.contributor.authorYazar, Enver
dc.date.accessioned2020-03-26T17:45:49Z
dc.date.available2020-03-26T17:45:49Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAbstract: The effect of tilmicosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into 3 groups. Lipopolysaccharide (250 µg, Escherichia coli 0111:B4, intraperitoneally) was injected into the positive control group. The other 2 groups received tilmicosin (20 mg kg, subcutaneously) concurrently without or with lipopolysaccharide. After treatment, serum samples were collected at 0, 1.5, 3, 6, 12 and 24 h. Serum tumor necrosis factor, interleukin-1 and interleukin-10 levels were determined by enzyme-linked immunosorbent assay. Lipopolysaccharide increased all cytokine levels in the healthy mice. Tilmicosin slightly induced interleukin-1 production in the healthy mice, while it had no effect on tumor necrosis factor or interleukin-10 productions. However, tilmicosin elevated (p<0.05) tumor necrosis factor, interleukin-1 and interleukin-10 levels in lipopolysaccharide-treated mice. In conclusion, these data suggest that tilmicosin stimulates both proinflammatory and antiinflammatory cytokines at the dose recommended for infection.en_US
dc.identifier.citationUney, K., Er, A., Avcı, G., Bülbül, A., Elmas, M., Yazar, E., (2009). Effect of Tilmicosin on Serum Cytokine Levels in the Endotoxemia. Journal of Animal and Veterinary Advances, 8(5), 1021-1024. Doi: 10.3923/javaa.2009.1021.1024
dc.identifier.doi10.3923/javaa.2009.1021.1024en_US
dc.identifier.endpage1024en_US
dc.identifier.issn1680-5593en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1021en_US
dc.identifier.urihttps://dx.doi.org/10.3923/javaa.2009.1021.1024
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24134
dc.identifier.volume8en_US
dc.identifier.wosWOS:000265889000037en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorUney, Kamil
dc.institutionauthorEr, Ayşe
dc.institutionauthorElmas, Muammer
dc.institutionauthorYazar, Enver
dc.language.isoenen_US
dc.relation.ispartofJournal of Animal and Veterinary Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIL-1en_US
dc.subjectIL-10en_US
dc.subjectLipopolysaccharideen_US
dc.subjectTilmicosinen_US
dc.subjectTNFen_US
dc.titleEffect of Tilmicosin on Serum Cytokine Levels in the Endotoxemiaen_US
dc.typeArticleen_US

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