Evaluation of c-MYC Status in Primary Acquired Cholesteatoma by Using Fluorescence in Situ Hybridization Technique

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dc.contributor.authorÖztürk, Kayhan
dc.contributor.authorYıldırım, Mahmut Selman
dc.contributor.authorAcar, Hasan
dc.contributor.authorCenik, Ziya
dc.contributor.authorKeleş, Bahar
dc.date.accessioned2020-03-26T17:03:31Z
dc.date.available2020-03-26T17:03:31Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The object of study was to investigate the status of c-MYC oncogene in primary acquired cholesteatoma. Study design: Descriptive study. Methods: Cholesteatoma samples were obtained from 15 patients with primary acquired cholesteatoma during surgical operation. Fluorescence in situ hybridization with a mixed DNA probe, which is specific for c-MYC located on 8q24 and chromosome 8 specific-alpha-satellite DNA probe (dual color), was used on the interphase nuclei. Results: Copy number of c-MYC oncogene and aneuploidy of chromosome 8 were 21.2% +/- 14.4% and 21.7% +/- 14.8%, respectively. There was no significant difference between copy number of c-MYC and frequency of chromosome 8 aneuploidy (p > 0.05). Ten of 15 cases showed different percentage of c-MYC and chromosome 8 aneuploidy, whereas 5 (33.3%) of 15 cases showed a normal distribution of c-MYC and chromosome 8 signals. Conclusion: The copy number of c-MYC in 10 of 15 cases was found to be high as observed for chromosome 8 aneuploidy in primary acquired cholesteatoma. These findings suggest that the ability of hyperproliferation of primary acquired cholesteatoma might have been related to c-MYC copy number by deregulating c-MYC expression.en_US
dc.identifier.citationÖztürk, K., Yıldırım, M. S., Acar, H., Cenik, Z., Keleş, B., (2006). Evaluation of c-MYC Status in Primary Acquired Cholesteatoma by Using Fluorescence in Situ Hybridization Technique. Otology & Neurotology, (27), 588-591. Doi: 10.1097/01.mao.0000226290.04048.d9
dc.identifier.doi10.1097/01.mao.0000226290.04048.d9en_US
dc.identifier.endpage591en_US
dc.identifier.issn1531-7129en_US
dc.identifier.pmid16868505en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage588en_US
dc.identifier.urihttps://dx.doi.org/10.1097/01.mao.0000226290.04048.d9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20480
dc.identifier.volume27en_US
dc.identifier.wosWOS:000239528500003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Kayhan
dc.institutionauthorYıldırım, Mahmut Selman
dc.institutionauthorAcar, Hasan
dc.institutionauthorCenik, Ziya
dc.institutionauthorKeleş, Bahar
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofOtology & Neurotologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectaneuploidyen_US
dc.subjectcholesteatomaen_US
dc.subjectchromosome 8en_US
dc.subjectc-MYCen_US
dc.subjectFISHen_US
dc.subjectoncogeneen_US
dc.titleEvaluation of c-MYC Status in Primary Acquired Cholesteatoma by Using Fluorescence in Situ Hybridization Techniqueen_US
dc.typeArticleen_US

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