Acute sleep deprivation is associated with increased QT dispersion in healthy young adults
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Sleep deprivation (SD) is known to be associated with worse cardiovascular outcome including mortality. We investigated the association between acute SD and electrocardiographic maximum QT interval (QTmax), QT, and corrected QT dispersion (QTd/cQTd), which ore known to be among predictors of ventricular arrhythmias and sudden death. Methods: We obtained electrocardiograms of 37 healthy young volunteers (age: 28.45 +/- 7.97 years; 11 women) after a night with regular sleep and repeated after a night with sleep debt. We measured minimum QT interval (QTmin), QTmax, QTd, and cQTd in milliseconds. Results: Average sleep time of the subjects were 7.7 +/- 0.8 hours during regular sleep and 1.7 +/- 1.6 hours during a night with sleep debt (P < 0.001). Subjects had similar values of QTmin in milliseconds after a night of sleep debt when compared to after regular sleep (347.56 +/- 29.75 vs 344.59 +/- 20.89; P = 0.51), whereas they had significantly higher values of QTmax, QTd, and cQTd (396.48 +/- 30.11 vs 378.10 +/- 23.90; P = 0.001, 49.45 +/- 9.11 vs 33.51 +/- 10.05; P < 0.001 and 54.92 +/- 10.42 vs 37.23 +/- 10.81; P < 0.001, respectively). In Pearson's correlation analysis, QTmax, QTd, and cQTd were inversely correlated with sleep time (P = 0.012, r = -0.291; P < 0.001, r = -0.625 and P < 0.001, r = -0.616, respectively). Conclusions: In conclusion, we clearly demonstrated that even one night of SD is associated with significant increase in QTmax, QTd, and cQTd in healthy young adults despite remaining within normal limits. These electrocardiographic changes in acute SD might contribute to development and/or recurrence of arrhythmias. This implication deserves further studies for clarifying the possible linkage between SD and arrhythmias.
Açıklama
Anahtar Kelimeler
acute sleep deprivation, QT dispersion
Kaynak
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
31
Sayı
8
