Acute sleep deprivation is associated with increased QT dispersion in healthy young adults

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dc.contributor.authorOzer, Orhan
dc.contributor.authorOzbala, Burcu
dc.contributor.authorSari, Ibrahim
dc.contributor.authorDavutoglu, Vedat
dc.contributor.authorMaden, Emin
dc.contributor.authorBaltaci, Yasemin
dc.contributor.authorYavuz, Sema
dc.date.accessioned2020-03-26T17:26:22Z
dc.date.available2020-03-26T17:26:22Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Sleep deprivation (SD) is known to be associated with worse cardiovascular outcome including mortality. We investigated the association between acute SD and electrocardiographic maximum QT interval (QTmax), QT, and corrected QT dispersion (QTd/cQTd), which ore known to be among predictors of ventricular arrhythmias and sudden death. Methods: We obtained electrocardiograms of 37 healthy young volunteers (age: 28.45 +/- 7.97 years; 11 women) after a night with regular sleep and repeated after a night with sleep debt. We measured minimum QT interval (QTmin), QTmax, QTd, and cQTd in milliseconds. Results: Average sleep time of the subjects were 7.7 +/- 0.8 hours during regular sleep and 1.7 +/- 1.6 hours during a night with sleep debt (P < 0.001). Subjects had similar values of QTmin in milliseconds after a night of sleep debt when compared to after regular sleep (347.56 +/- 29.75 vs 344.59 +/- 20.89; P = 0.51), whereas they had significantly higher values of QTmax, QTd, and cQTd (396.48 +/- 30.11 vs 378.10 +/- 23.90; P = 0.001, 49.45 +/- 9.11 vs 33.51 +/- 10.05; P < 0.001 and 54.92 +/- 10.42 vs 37.23 +/- 10.81; P < 0.001, respectively). In Pearson's correlation analysis, QTmax, QTd, and cQTd were inversely correlated with sleep time (P = 0.012, r = -0.291; P < 0.001, r = -0.625 and P < 0.001, r = -0.616, respectively). Conclusions: In conclusion, we clearly demonstrated that even one night of SD is associated with significant increase in QTmax, QTd, and cQTd in healthy young adults despite remaining within normal limits. These electrocardiographic changes in acute SD might contribute to development and/or recurrence of arrhythmias. This implication deserves further studies for clarifying the possible linkage between SD and arrhythmias.en_US
dc.identifier.doi10.1111/j.1540-8159.2008.01125.xen_US
dc.identifier.endpage984en_US
dc.identifier.issn0147-8389en_US
dc.identifier.issn1540-8159en_US
dc.identifier.issue8en_US
dc.identifier.pmid18684254en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage979en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1540-8159.2008.01125.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22182
dc.identifier.volume31en_US
dc.identifier.wosWOS:000258397500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofPACE-PACING AND CLINICAL ELECTROPHYSIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectacute sleep deprivationen_US
dc.subjectQT dispersionen_US
dc.titleAcute sleep deprivation is associated with increased QT dispersion in healthy young adultsen_US
dc.typeArticleen_US

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