Pharmacokinetics of Cefquinome in Red-eared Slider Turtles (Trachemys Scripta Elegans) After Single Intravenous and Intramuscular Injections

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dc.authorid0000-0002-8674-4873
dc.authorid0000-0002-9017-763X
dc.authorid0000-0003-2738-6911
dc.authorid0000-0001-9059-7151
dc.contributor.authorÜney, Kamil
dc.contributor.authorAltan, Feray
dc.contributor.authorÇetin, Gül
dc.contributor.authorAboubakr, Mohamed
dc.contributor.authorDik, Burak
dc.contributor.authorSayın, Zafer
dc.contributor.authorEr, Ayşe
dc.contributor.authorElmas, Muammer
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThe purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2 mg/kg body weight in red-eared slider turtles. Plasma concentrations of CFQ were determined by high-performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: elimination half-life (t1/2λz) 21.73 ± 4.95 hr, volume of distribution at steady-state (Vdss) 0.37 ± 0.11 L/kg, area under the plasma concentration–time curve (AUC0–∞) 163 ± 32 μg hr−1 ml−1, and total body clearance (ClT) 12.66 ± 2.51 ml hr−1 kg−1. The pharmacokinetic parameters after IM injection were as follows: peak plasma concentration (Cmax) 3.94 ± 0.84 μg/ml, time to peak concentration (Tmax) 3 hr, t1/2λz 26.90 ± 4.33 hr, and AUC0–∞ 145 ± 48 μg hr−1 ml−1. The bioavailability after IM injection was 88%. Data suggest that CFQ has a favorable pharmacokinetic profile with a long half-life and a high bioavailability in red-eared slider turtles. Further studies are needed to establish a multiple dosage regimen and evaluate clinical efficacy.
dc.description.abstract[Abstract not Available]en_US
dc.identifier.citationÜney, K., Altan, F., Çetin, G., Aboubakr, M., Dik, B., Sayın, Z., Er, A., Elmas, M. (2018). Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections. Journal of Veterinary Pharmacology and Therapeutics, 41, (1), 40-44.
dc.identifier.doi10.1111/jvp.12448en_US
dc.identifier.endpage44
dc.identifier.issn1365-2885en_US
dc.identifier.issue1
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage40
dc.identifier.urihttps://doi.org/10.1111/jvp.12448
dc.identifier.volume41
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDik, Burak
dc.institutionauthorElmas, Muammer
dc.institutionauthorSayın, Zafer
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltd
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.selcuk20240510_oaigen_US
dc.subjectTrachemys scripta elegans
dc.subjectPharmacokinetic
dc.subjectFarmakokinetik
dc.subjectKırmızı kulaklı kayan kaplumbağalar
dc.subjectRed-eared slider turtles
dc.subjectIntramüsküler enjeksiyon
dc.subjectIntramuscular injection
dc.subjectCefquinome
dc.subjectSefkinom
dc.subjectIntravenous injection
dc.subjectİntravenöz enjeksiyon
dc.titlePharmacokinetics of Cefquinome in Red-eared Slider Turtles (Trachemys Scripta Elegans) After Single Intravenous and Intramuscular Injectionsen_US
dc.typeArticleen_US

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