Detection and Quantification of Herpesviruses in Kostmann Syndrome Periodontitis Using Real-Time Polymerase Chain Reaction: A Case Report

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dc.contributor.authorYıldırım, S.
dc.contributor.authorYapar, M.
dc.contributor.authorKubar, A.
dc.date.accessioned2020-03-26T17:03:19Z
dc.date.available2020-03-26T17:03:19Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/aims: Kostmann syndrome, or severe congenital neutropenia, is an autosomal recessive disease of neutrophil production and is associated with severe periodontal pathology. The aim of this study was to determine whether human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) contribute to the pathogenesis of Kostmann syndrome periodontitis. Methods: Supragingival plaque and saliva samples were taken from a 6-year-old boy and his 3-year-old sister suffering from Kostmann syndrome, and from two age- and gender-matched healthy children serving as controls. The samples were taken before and 24 months after periodontal treatment. Real-time polymerase chain reaction (TaqMan Real-Time PCR) assay was used to quantify HCMV and EBV DNA. Results: EBV was detected in baseline samples from the Kostmann syndrome patients but not in samples from the healthy control subjects. HCMV was only detected in the saliva of the boy with Kostman syndrome at baseline. Herpesviruses numbers decreased dramatically in the post-treatment samples. Conclusion: EBV and HCMV were detected in the two subjects with Kostmann syndrome periodontitis. The results of the study indicate that nonsurgical treatment of Kostmann syndrome periodontitis can reduce supragingival and salivary herpes viral loads.en_US
dc.identifier.citationYıldırım, S., Yapar, M., Kubar, A., (2006). Detection and Quantification of Herpesviruses in Kostmann Syndrome Periodontitis Using Real-Time Polymerase Chain Reaction: A Case Report. Oral Microbiology and Immunology, (21), 73-78. Doi: 10.1111/j.1399-302X.2006.00250.x
dc.identifier.doi10.1111/j.1399-302X.2006.00250.xen_US
dc.identifier.endpage78en_US
dc.identifier.issn0902-0055en_US
dc.identifier.pmid16476015en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1399-302X.2006.00250.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20424
dc.identifier.volume21en_US
dc.identifier.wosWOS:000235333400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYıldırım, S.
dc.language.isoenen_US
dc.publisherWıleyen_US
dc.relation.ispartofOral Microbiology and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcytomegalovirusen_US
dc.subjectEpstein-Barr virusen_US
dc.subjectherpesvirusen_US
dc.subjectKostmann syndromeen_US
dc.subjectsevere congenital neutropeniaen_US
dc.subjectperiodontal diseaseen_US
dc.titleDetection and Quantification of Herpesviruses in Kostmann Syndrome Periodontitis Using Real-Time Polymerase Chain Reaction: A Case Reporten_US
dc.typeArticleen_US

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