Bioavailability and Pharmacokinetic Profile of Levofloxacin Following Intravenous, Intramuscular and Oral Administration in Turkeys

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dc.contributor.authorAboubakr, Mohamed
dc.contributor.authorÜney, Kamil
dc.contributor.authorElmas, Muammer
dc.date.accessioned2020-03-26T18:49:35Z
dc.date.available2020-03-26T18:49:35Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstract1. The pharmacokinetics and bioavailability of levofloxacin in turkeys were investigated after a single intravenous (IV), intramuscular (IM) and oral (PO) administration of 10mg/kg body weight.2. The concentrations of levofloxacin in plasma samples were assayed using a microbiological assay method and pharmacokinetic parameters were calculated by non-compartmental analysis.3. Following IV administration, the elimination half-life (t(0.5())), volume of distribution at steady state (Vd(ss)) and total body clearance (Cl) were 4.49h, 1.31l/kg and 0.23l/h/kg, respectively.4. After single IM and PO administrations at the same dose, levofloxacin was rapidly absorbed as indicated by an absorption half-life (t(0.5ab)) of 1.02 and 0.76h, respectively; maximum plasma concentrations (C-max) of 5.59 and 5.15g/ml were obtained at a maximum time (T-max) of 2 h for both routes and levofloxacin bioavailability (F) was 96.5h and 79.9% respectively after IM and PO administration. In vitro plasma protein binding of levofloxacin was 24.3%.5. Based on these pharmacokinetic parameters, a dose of 10mg/kg body weight given intramuscularly or orally every 24h in turkeys can maintain effective plasma concentrations with bacterial infections with (minimum inhibitory concentration) MIC90>0.1g/ml.en_US
dc.identifier.citationAboubakr, M., Üney, K., Elmas, M. (2014). Bioavailability and pharmacokinetic profile of levofloxacin following intravenous, intramuscular and oral administration in Turkeys. British Poultry Science, 56, (1), 115-119.
dc.identifier.doi10.1080/00071668.2013.860214en_US
dc.identifier.endpage119en_US
dc.identifier.issn0007-1668en_US
dc.identifier.issn1466-1799en_US
dc.identifier.issue1en_US
dc.identifier.pmid24735473en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00071668.2013.860214
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30641
dc.identifier.volume55en_US
dc.identifier.wosWOS:000334399200015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorElmas, Muammer
dc.institutionauthorÜney, Kamil
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofBritish Poultry Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBioavailability
dc.subjectPharmacokinetic profile
dc.subjectBiyoyararlanım
dc.subjectFarmakokinetik profili
dc.subjectLevofloxacin
dc.subjectLevofloksasin
dc.subjectOral administration
dc.subjectOral uygulama
dc.subjectIntravenous enjection
dc.subjectİntravenöz enjeksiyon
dc.subjectIntramuscular enjection
dc.subjectİntramüsküler enjeksiyon
dc.titleBioavailability and Pharmacokinetic Profile of Levofloxacin Following Intravenous, Intramuscular and Oral Administration in Turkeysen_US
dc.typeArticleen_US

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