DNA damaging effect of paclitaxel in the epididymal sperms as a chemotherapeutic agent and possible remedies to prevent this effect: A study on reproductive potential of male cancer patients of reproductive age

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dc.contributor.authorIli, Pinar.
dc.contributor.authorSari, Fikret.
dc.contributor.authorBucak, Mustafa Numan.
dc.contributor.authorÖztürk, Caner.
dc.contributor.authorGüngör, Şükrü.
dc.contributor.authorAtaman, Mehmet Bozkurt.
dc.date.accessioned2020-03-26T20:13:29Z
dc.date.available2020-03-26T20:13:29Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractCancer is a major public health problem, young cancer patients therefore undergo chemotherapy, and most of them may lose their fertility. DNA damage level provides important clues about the quality and reproductive potential of spermatozoa. In this study, we evaluated the levels of both DNA fragmentation and abnormal DNA integrity in the epididymal sperms of New Zealand rabbit (thyctolagus cuniculus) after cryopreservation using the terminal deoxyribonucleotidyl transferase-mediated dUTP nick end-labelling (TUNEL) assay and the toluidine blue (TB) staining methods and assessed the effects of paclitaxel, resveratrol, L-glutamine (LG), and basal medium eagle (BME) solution on DNA damage. Paclitaxel induced the levels of both DNA damages in the sperms, but resveratrol ameliorated this effect. LG and BME supplementation to the extender prevented the sperm samples from DNA fragmentation after cryopreservation. Chemotherapy drugs containing paclitaxel can cause the sperm DNA to be damaged, and hence adversely affect the fertility of male cancer patients of reproductive age. The administration of resveratrol together with paclitaxel may ameliorate the DNA damage inducing effect of paclitaxel. Sperm banking and cryopreservation with the appropriate cryoprotectants such as LG and BME prior to cancer treatment can also be suggested to all male cancer patients of reproductive age facing cancer treatment for fertility preservation. (C) 2019 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research ProjectsSelcuk University [12102013]en_US
dc.description.sponsorshipA part of this study was supported by Selcuk University Scientific Research Projects (grant no: 12102013). Preliminary findings of this study were presented as a poster at the 3rd International Symposium on EuroAsian Biodiversity (SEAB2017), Minsk, Belarus, July 2017.en_US
dc.identifier.citationIli, P., Sari, F., Bucak, M. N., Öztürk, C., Güngör, Ş., Ataman, M. B. (2019). DNA Damaging Effect of Paclitaxel in the Epididymal Sperms as a Chemotherapeutic Agent and Possible Remedies to Prevent This Effect: A Study on Reproductive Potential of Male Cancer Patients of Reproductive Age. Theriogenology, 132, 201-211.
dc.identifier.doi10.1016/j.theriogenology.2019.04.015en_US
dc.identifier.endpage211en_US
dc.identifier.issn0093-691Xen_US
dc.identifier.issn1879-3231en_US
dc.identifier.pmid31029850en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.theriogenology.2019.04.015
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37702
dc.identifier.volume132en_US
dc.identifier.wosWOS:000469159900023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBucak, Mustafa Numan.
dc.institutionauthorAtaman, Mehmet Bozkurt.
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofTHERIOGENOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPaclitaxelen_US
dc.subjectResveratrolen_US
dc.subjectDNA damageen_US
dc.subjectCryopreservationen_US
dc.subjectCanceren_US
dc.subjectFertilityen_US
dc.titleDNA damaging effect of paclitaxel in the epididymal sperms as a chemotherapeutic agent and possible remedies to prevent this effect: A study on reproductive potential of male cancer patients of reproductive ageen_US
dc.typeArticleen_US

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