The in vitro effects of remifentanil and fentanyl on isolated human right atria and saphenous veins
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B SAUNDERS CO
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To determine the myocardial and vascular effects of remifentanil and fentanyl in human atria and saphenous veins. Design: In vitro, prospective with repeated measures. Setting: University research laboratory. Interventions: The direct effects of remifentanil and fentanyl on the electrical stimulation-induced contraction of nonfailing human atrium and saphenous veins contracted with 5-hydroxytryptamine were studied. Measurements and Main Results: In human atrial trabeculae, cumulative (10(-9)-10(-5) mol/L) added remifentanil had in 0 effect on contractile force, compared with untreated muscles (p > 0.05). The force of contraction was significantly less than control values with concentrations of fentanyl ranging from 10(-8) to 10(-5) mol/L (p < 0.05). At the highest concentration (10(-5) mol/L), the inhibition by fentanyl of the electrical stimulation-induced contraction was 40.6% +/- 6.32%. In human saphenous vein strips preconstricted with 5-hydroxytryptamine, remifentanil (10(-8)-10(-5) mol/L) and fentanyl (10(-8)-10(-5) mol/L) produced "concentration-dependent" relaxation when compared with the control contraction value (p < 0.05). The IC50 was similar with remifentanil and fentanyl and the E-max of fentanyl was significantly higher than remifentanil (p < 0.05). The venodilatory effects of remifentanil and fentanyl were similar on veins with or without endothelium (p > 0.05). Conclusions: Remifentanil has no direct effect on the contraction of myocardium. Fentanyl inhibits the electrical stimulation-induced contraction in human right atrial muscles in vitro. Remifentanil and fentanyl produce "concentration-dependent" relaxation in human saphenous vein strips independent from the endothelium. (C) 2003 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
fentanyl, remifentanil, human atrium, human saphenous vein, myocardial contractility, in vitro
Kaynak
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
17
Sayı
4
