The in vitro effects of remifentanil and fentanyl on isolated human right atria and saphenous veins

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dc.contributor.authorDuman, A
dc.contributor.authorSahin, AS
dc.contributor.authorAtalik, KE
dc.contributor.authorOgun, C
dc.contributor.authorUlusoy, HB
dc.contributor.authorDurgut, K
dc.contributor.authorOkesli, S
dc.date.accessioned2020-03-26T16:46:14Z
dc.date.available2020-03-26T16:46:14Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To determine the myocardial and vascular effects of remifentanil and fentanyl in human atria and saphenous veins. Design: In vitro, prospective with repeated measures. Setting: University research laboratory. Interventions: The direct effects of remifentanil and fentanyl on the electrical stimulation-induced contraction of nonfailing human atrium and saphenous veins contracted with 5-hydroxytryptamine were studied. Measurements and Main Results: In human atrial trabeculae, cumulative (10(-9)-10(-5) mol/L) added remifentanil had in 0 effect on contractile force, compared with untreated muscles (p > 0.05). The force of contraction was significantly less than control values with concentrations of fentanyl ranging from 10(-8) to 10(-5) mol/L (p < 0.05). At the highest concentration (10(-5) mol/L), the inhibition by fentanyl of the electrical stimulation-induced contraction was 40.6% +/- 6.32%. In human saphenous vein strips preconstricted with 5-hydroxytryptamine, remifentanil (10(-8)-10(-5) mol/L) and fentanyl (10(-8)-10(-5) mol/L) produced "concentration-dependent" relaxation when compared with the control contraction value (p < 0.05). The IC50 was similar with remifentanil and fentanyl and the E-max of fentanyl was significantly higher than remifentanil (p < 0.05). The venodilatory effects of remifentanil and fentanyl were similar on veins with or without endothelium (p > 0.05). Conclusions: Remifentanil has no direct effect on the contraction of myocardium. Fentanyl inhibits the electrical stimulation-induced contraction in human right atrial muscles in vitro. Remifentanil and fentanyl produce "concentration-dependent" relaxation in human saphenous vein strips independent from the endothelium. (C) 2003 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/S1053-0770(03)00151-4en_US
dc.identifier.endpage469en_US
dc.identifier.issn1053-0770en_US
dc.identifier.issue4en_US
dc.identifier.pmid12968234en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S1053-0770(03)00151-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18600
dc.identifier.volume17en_US
dc.identifier.wosWOS:000185033500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS COen_US
dc.relation.ispartofJOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectfentanylen_US
dc.subjectremifentanilen_US
dc.subjecthuman atriumen_US
dc.subjecthuman saphenous veinen_US
dc.subjectmyocardial contractilityen_US
dc.subjectin vitroen_US
dc.titleThe in vitro effects of remifentanil and fentanyl on isolated human right atria and saphenous veinsen_US
dc.typeArticleen_US

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