Combination Antioxidant Effect of Alpha-Tocoferol and Erdosteine in Ischemia-Reperfusion Injury in Rat Model

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dc.contributor.authorYurdakul, Talat
dc.contributor.authorKulaksızoğlu, Haluk
dc.contributor.authorPişkin, Mehmet Mesut
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorErtemli, Esra
dc.contributor.authorBarışkaner, Hulagü
dc.contributor.authorBüyükbaş, Sadık
dc.contributor.authorKocabaş, Volkan
dc.date.accessioned2020-03-26T17:47:28Z
dc.date.available2020-03-26T17:47:28Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction Renal ischemia/reperfusion (I/R) which is an important cause of renal dysfunction is inevitable in renal transplantation, surgical revascularization of the renal artery, partial nephrectomy and treatment of suprarenal aortic aneurysms. Aim The purpose of this study was to investigate the efficacy of alpha-tocopherol and erdosteine combination in the reduction in injury induced by ROS in a rat model of renal ischemia-reperfusion. Materials and methods Thirty-six-male Wistar albino rats weighing 200-250 g were utilized for this study. Rats were divided into six groups, and each group was consistent of six rats: (1) sham-operated (control), (2) ischemia group (3) I/R group, (4) I/R/alpha-tocoferol group (5) I/erdosteine group (6). I/R/alpha-tocoferol and erdosteine group. Biochemically tissue MDA, XO and SOD activities, light and electron microscopic findings were evaluated. Results The erdosteine and alpha-tocoferol significantly reversed the effect of protein oxidation and lipid peroxidation induced by I/R shown by the decreased levels of MDA and XO activities. Both MDA and XO levels were found to be lower in group 6 compared to single agent treatment groups, and this was significantly different. All treatment groups showed increased SOD activity, which accounts for their oxidative properties. The mean Paller score of the combination treatment group (group 6) was lower than all groups except the sham group (3.67 +/- 1.2), and this finding was statistically significant (0.05). Our results showed that the antioxidant pretreatment with alpha-tocopherol and erdosteine combination reduced lipid peroxidation of renal cellular membranes in a model of normothermic renal ischemia-reperfusion in rats. Combination of erdosteine and alpha-tocopherol has a synergistic effect of protection against oxidative processes. Long-term use of alpha-tocopherol seems to have a greater effect on the prevention of IR injury. However, further investigations are needed for the clinical applications of our findings.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study was supported by the Selcuk University Research Fund.en_US
dc.identifier.citationYurdakul, T., Kulaksızoğlu, H., Pişkin, M. M., Avunduk, M. C., Ertemli, E., Barışkaner, H., Büyükbaş, S., Kocabaş, V., (2010). Combination Antioxidant Effect of Alpha-Tocoferol and Erdosteine in Ischemia-Reperfusion Injury in Rat Model. International Urology and Nephrology, (42), 647-655. Doi: 10.1007/s11255-009-9641-y
dc.identifier.doi10.1007/s11255-009-9641-yen_US
dc.identifier.endpage655en_US
dc.identifier.issn0301-1623en_US
dc.identifier.issn1573-2584en_US
dc.identifier.pmid19789992en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage647en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11255-009-9641-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24705
dc.identifier.volume42en_US
dc.identifier.wosWOS:000284910500015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYurdakul, Talat
dc.institutionauthorKulaksızoğlu, Haluk
dc.institutionauthorPişkin, Mehmet Mesut
dc.institutionauthorAvunduk, Mustafa Cihat
dc.institutionauthorBarışkaner, Hulagü
dc.institutionauthorBüyükbaş, Sadık
dc.institutionauthorKocabaş, Volkan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectAntioxidantsen_US
dc.subjectErdosteineen_US
dc.subjectalpha-Tocopherolen_US
dc.subjectKidneyen_US
dc.titleCombination Antioxidant Effect of Alpha-Tocoferol and Erdosteine in Ischemia-Reperfusion Injury in Rat Modelen_US
dc.typeArticleen_US

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