Parentucellia latifolia subsp. latifolia: A potential source for loganin iridoids by HPLC-ESI-MSn technique
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE BV
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study attempts to compare the pharmaceutical potential (antioxidant and key enzyme inhibition of clinical relevance) of organic and aqueous extracts of Parentucellia latifolia (L) Caruel subsp. latifolia (L) Caruel as well as phytochemical composition. The phytochemical compounds were evaluated by spectrophotometric methods (for total amounts) and HPLC-ESI-DAD-MSn (for individual compounds). The extracts were screened for antioxidant abilities by in vitro assays. Inhibition effects were also investigated against a set of enzymes linked to major health problems. Generally, the methanol (MeOH) and aqueous extracts displayed higher scavenging abilities on radicals and reductive effects when compared with the ethyl acetate (EtOAc) extract. On the other hand, the EtOAc extract was the most active inhibitor on cholinesterases (1.81-1.88 mg GALAE/g), amylase (0.70 mmol ACAE/g), glucosidase (2.85 mmol ACAE/g) and lipase (33.24 mg OE/g). The highest TPC was observed in the aqueous extract (25.07 mg GAE/g) while MeOH extract possessed the highest level of TFC (44.15 mg RE/g) and TPAC (3.46 mg CE/g). LCMSn metabolite profiling indicated that loganin and its isomers, rutin, and luteolin-O-hexoside were the most abundant compounds. Our results suggest that P. latifolia may be valuable source of phyto-agents for the management of noncommunicable diseases. (C) 2018 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Parentucellia latifolia, Antioxidants, Enzyme inhibition, Phenolic, Flavonoid, Loganin
Kaynak
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
165
Sayı
Künye
Llorent-Martínez, E. J., Fernández-de Córdova, M. L., Zengin, G., Bahadori, M. B., Aumeeruddy, M. Z., Rengasamy, K. R., Mahomoodally, M. F. (2019). Parentucellia Latifolia Subsp. Latifolia: A Potential Source For Loganin İridoids By HPLC-ESI-Msn Technique. Journal Of Pharmaceutical And Biomedical Analysis, 165, 374-380.
