Parentucellia latifolia subsp. latifolia: A potential source for loganin iridoids by HPLC-ESI-MSn technique

Basit Öğe Kaydı
dc.contributor.authorLlorent-Martinez, Eulogio J.
dc.contributor.authorFernandez-de Cordova, Maria Luisa
dc.contributor.authorZengin, Gökhan
dc.contributor.authorBahadori, Mir Babak
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorRengasamy, Kannan R. R.
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:19:06Z
dc.date.available2020-03-26T20:19:06Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThis study attempts to compare the pharmaceutical potential (antioxidant and key enzyme inhibition of clinical relevance) of organic and aqueous extracts of Parentucellia latifolia (L) Caruel subsp. latifolia (L) Caruel as well as phytochemical composition. The phytochemical compounds were evaluated by spectrophotometric methods (for total amounts) and HPLC-ESI-DAD-MSn (for individual compounds). The extracts were screened for antioxidant abilities by in vitro assays. Inhibition effects were also investigated against a set of enzymes linked to major health problems. Generally, the methanol (MeOH) and aqueous extracts displayed higher scavenging abilities on radicals and reductive effects when compared with the ethyl acetate (EtOAc) extract. On the other hand, the EtOAc extract was the most active inhibitor on cholinesterases (1.81-1.88 mg GALAE/g), amylase (0.70 mmol ACAE/g), glucosidase (2.85 mmol ACAE/g) and lipase (33.24 mg OE/g). The highest TPC was observed in the aqueous extract (25.07 mg GAE/g) while MeOH extract possessed the highest level of TFC (44.15 mg RE/g) and TPAC (3.46 mg CE/g). LCMSn metabolite profiling indicated that loganin and its isomers, rutin, and luteolin-O-hexoside were the most abundant compounds. Our results suggest that P. latifolia may be valuable source of phyto-agents for the management of noncommunicable diseases. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.identifier.citationLlorent-Martínez, E. J., Fernández-de Córdova, M. L., Zengin, G., Bahadori, M. B., Aumeeruddy, M. Z., Rengasamy, K. R., Mahomoodally, M. F. (2019). Parentucellia Latifolia Subsp. Latifolia: A Potential Source For Loganin İridoids By HPLC-ESI-Msn Technique. Journal Of Pharmaceutical And Biomedical Analysis, 165, 374-380.
dc.identifier.doi10.1016/j.jpba.2018.12.025en_US
dc.identifier.endpage380en_US
dc.identifier.issn0731-7085en_US
dc.identifier.issn1873-264Xen_US
dc.identifier.pmid30590334en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpba.2018.12.025
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38070
dc.identifier.volume165en_US
dc.identifier.wosWOS:000456899500044en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectParentucellia latifoliaen_US
dc.subjectAntioxidantsen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPhenolicen_US
dc.subjectFlavonoiden_US
dc.subjectLoganinen_US
dc.titleParentucellia latifolia subsp. latifolia: A potential source for loganin iridoids by HPLC-ESI-MSn techniqueen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Gökhan zengin3.pdf
Boyut:
604.62 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Biyoloji/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu