Growth Promoting Effects of Human Placental Lactogen During Early Organogenesis: A Link to Insulin-Like Growth Factors

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dc.contributor.authorKarabulut, Ahmet Kağan
dc.contributor.authorLayfield, Robert
dc.contributor.authorPratten, Margaret K.
dc.date.accessioned2020-03-26T16:37:10Z
dc.date.available2020-03-26T16:37:10Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMany maternally derived factors may be involved in the regulation of embryonic growth but the control mechanisms involved are poorly understood. Human placental lactogen (hPL) has been implicated in playing a role in the control of embryonic growth. Several investigators suggested that there may be a possible link between the effects of this hormone and insulin-like growth factors (IGFs). In order to determine the growth promoting potential of hPL and involvement of IGFs in the mechanism of action of the hormone, 9.5 d rat embryos were cultured in vitro for 48 h in depleted serum in the presence and absence of hPL with additional IGF antisera. The growth supporting capacity of the serum was reduced by removal of low molecular weight molecules by prolonged filtration of the serum using filters with a molecular weight exclusion of 30 kDa. Addition of hPL (3.2-25.6 ng/ml) to depleted serum significantly improved embryonic growth and development, suggesting that the developing embryo may utilise hPL. The presence of antisera against hPL, IGF-I and -II abolished the hPL-induced increase in the development in all parameters suggesting that there may be a possible link between the IGFs and the effects of hPL on rat embryonic development and this hormone may achieve its growth promoting effects via IGFs.en_US
dc.identifier.citationKarabulut, A. K., Layfield, R., Pratten, M. K., (2001). Growth Promoting Effects of Human Placental Lactogen During Early Organogenesis: A Link to Insulin-Like Growth Factors. Journal of Anatomy, (198), 651-662.
dc.identifier.endpage662en_US
dc.identifier.issn0021-8782en_US
dc.identifier.issn1469-7580en_US
dc.identifier.pmid11465858en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage651en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17554
dc.identifier.volume198en_US
dc.identifier.wosWOS:000169944800002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarabulut, Ahmet Kağan
dc.language.isoenen_US
dc.publisherWıleyen_US
dc.relation.ispartofJournal of Anatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectembryo growthen_US
dc.subjectplacental lactogenen_US
dc.subjectinsulin-like growth factorsen_US
dc.titleGrowth Promoting Effects of Human Placental Lactogen During Early Organogenesis: A Link to Insulin-Like Growth Factorsen_US
dc.typeArticleen_US

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