The role of hyperbaric oxygen in the management of subarachnoid hemorrhage
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Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGER
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To determine the role of hyperoxic and hyperbaric therapy following experimental subarachnoid hemorrhage (SAH). Design: Prospective, randomized, controlled animal study. Subjects: Thirty male Wistar rats. Interventions: Thirty rats were assessed for an initial neurologic status as double-blinded by two different neurosurgeons using a neurologic severity score (NSS) and then underwent an initial angiographic examination. Two days later, 0.3 ml of homologous blood was injected into the cisterna magna to produce a SAH-induced cerebral vasospasm. The NSS and angiographic examination were then repeated. The rats having no spasm or a spasm under 50% (n=8) and 50% or over 50% (n=22) were grouped separately, as groups 1 and 2, respectively. The rats having 50% or more spasm were further divided randomly into group 2A and 2B. The rats in groups 1 and 2A (n= 11) underwent a 60-min course of 100% oxygen at the atmospheric pressure 1 atmosphere absolute (ata), and group 2B (n= 11) received 100% oxygen at 3 ata for I h. Neurologic assessment was repeated on the next day and 7 days later. Measurements and main results: The animals having no spasm or less than 50% spasm had a better NSS and outcome when compared with the animals having 50% or more spasm. But the animals with 50% or more spasm which underwent hyperbaric therapy were shown to have a better outcome compared to the animals having hyperoxic therapy. Conclusion: Exposure to hyperbaric oxygen therapy seemed to accelerate the recovery of neurologic deficits secondary to experimental SAH.
Açıklama
Anahtar Kelimeler
subarachnoid hemorrhage, hyperbaric oxygen, vasospasm, rat, angiography
Kaynak
INTENSIVE CARE MEDICINE
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
30
Sayı
1
