Pharmacokinetics of cefquinome after single and repeated subcutaneous administrations in sheep

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dc.authorid0000-0003-3168-2510
dc.authorid0000-0003-1567-991X
dc.authorid0000-0002-8674-4873
dc.contributor.authorCorum, Orhan.
dc.contributor.authorCorum, Duygu Durna.
dc.contributor.authorEr, Ayse.
dc.contributor.authorUney, Kamil.
dc.date.accessioned2020-03-26T20:19:07Z
dc.date.available2020-03-26T20:19:07Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThe purpose of this study was to determine the pharmacokinetics of cefquinome (CFQ) following single and repeated subcutaneous (SC) administrations in sheep. Six clinically healthy, 1.5 +/- 0.2 years sheep were used for the study. In pharmacokinetic study, the crossover design in three periods was performed. The withdrawal interval between the study periods was 15 days. In first period, CFQ (Cobactan, 2.5%) was administered by an intravenous (IV) bolus (3 sheep) and SC (3 sheep) injections at 2.5 mg/kg dose. In second period, the treatment administration was repeated via the opposite administration route. In third period, CFQ was administrated subcutaneously to each sheep (n = 6) at a dose of 2.5 mg/kg q. 24 hr for 5 days. Plasma concentrations of CFQ were measured using the HPLC-UV method. Pharmacokinetic parameters were calculated using non-compartmental methods. The elimination half-life and mean residence time of CFQ after the single SC administration were longer than IV administration (p < 0.05). Bioavailability (F%) of CFQ following the single SC administration was 123.51 +/- 11.54%. The area under the curve (AUC(0-infinity)) and peak concentration following repeated doses (last dose) were higher than those observed after the first dose (p < 0.05). CFQ accumulated after repeated SC doses. CFQ can be given via SC at a dose of 2.5 mg/kg every 24 hr for the treatment of infections caused by susceptible pathogens, which minimum inhibitory concentration is <= 1.0 mu g/ml in sheep.en_US
dc.description.sponsorshipThe Coordination Unit of Scientific Research Projects, University of Selcuk, Turkey [15401151]en_US
dc.identifier.citationCorum, O., Corum, D. D., Er, A., Uney, K. (2019). Pharmacokinetics of Cefquinome After Single and Repeated Subcutaneous Administrations in Sheep. Journal of Veterinary Pharmacology and Therapeutics, 42(6), 647-653.
dc.identifier.doi10.1111/jvp.12750en_US
dc.identifier.endpage653en_US
dc.identifier.issn0140-7783en_US
dc.identifier.issn1365-2885en_US
dc.identifier.issue6en_US
dc.identifier.pmid30719732en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage647en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jvp.12750
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38081
dc.identifier.volume42en_US
dc.identifier.wosWOS:000501034000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEr, Ayse.
dc.institutionauthorUney, Kamil.
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbioavailabilityen_US
dc.subjectcefquinomeen_US
dc.subjectpharmacokineticsen_US
dc.subjectsheepen_US
dc.subjectsubcutaneousen_US
dc.titlePharmacokinetics of cefquinome after single and repeated subcutaneous administrations in sheepen_US
dc.typeArticleen_US

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