Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations

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dc.contributor.authorBender, Onur
dc.contributor.authorLlorent-Martinez, Eulogio J.
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMollica, Adriano
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorMolina-Garcia, Lucia
dc.contributor.authorFernandez-de Cordova, Maria Luisa
dc.contributor.authorAtalay, Arzu
dc.date.accessioned2020-03-26T19:54:23Z
dc.date.available2020-03-26T19:54:23Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü.en_US
dc.description.abstractThe genus Hypericum is one of the most popular genera in both traditional medicine and scientific platform. This study is designed to provide conceptual insights on the biological potential and chemical characterization of H. salsugineum, which is endemic to Turkey. The qualitative and quantitative phenolic content of the extracts was characterized by HPLC-ESI-MSn. Biological efficiency was investigated by enzyme inhibitory assays (cholinesterases, tyrosinase, amylase, and glucosidase) and anti-cancer efficacy tests (anti-proliferative activities with the iCELLigence technology, colony formation and wound healing scratch assays). Phenolic acids (3-O-caffeoylquinic, 5-O-caffeoylquinic, and 4-O-caffeoylquinic acids) were the predominant group in the studied extracts, although several flavonoids were also detected and quantified. The extracts exhibited good inhibitory effects on tyrosinase and glucosidase, while they had weak ability against cholinesterases and amylase. Computational studies were also performed to explain the interactions between the major phenolics and these enzymes. The extracts displayed significant anti-cancer effects on breast carcinoma cell lines. Our findings suggest that Hypericum salsugineum could be valued as a potential source of biologically-active compounds for designing novel products.en_US
dc.identifier.citationBender, O., Martinez, E. J. L., Zengin, G., Mollica, A., Ceylan, R., Garcia, L. M., Cordova, M. L. F., Atalay, A. (2018). Integration of in Vitro and in Silico Perspectives to Explain Chemical Characterization, Biological Potential and Anticancer Effects of Hypericum Salsugineum: A Pharmacologically Active Source for Functional Drug Formulations. Plos One, 13(6).
dc.identifier.doi10.1371/journal.pone.0197815en_US
dc.identifier.issn1932-6203en_US
dc.identifier.issue6en_US
dc.identifier.pmid29864137en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1371/journal.pone.0197815
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36719
dc.identifier.volume13en_US
dc.identifier.wosWOS:000434097100010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.institutionauthorCeylan, Ramazan
dc.language.isoenen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.relation.ispartofPLOS ONEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChemical characterizationen_US
dc.subjectHypericum salsugineumen_US
dc.subjectAnticancer effecten_US
dc.subjectFunctional drug formulationen_US
dc.titleIntegration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulationsen_US
dc.typeArticleen_US

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