Voluntary, involuntary and forced exercises almost equally reverse behavioral impairment by regulating hippocampal neurotrophic factors and oxidative stress in experimental Alzheimer's disease model

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dc.contributor.authorBelviranli, Muaz.
dc.contributor.authorOkudan, Nilsel.
dc.date.accessioned2020-03-26T20:19:44Z
dc.date.available2020-03-26T20:19:44Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe purpose of this study was to compare the neuroprotective effects of voluntary, involuntary, and forced exercise trainings on behavioral impairment as well as hippocampal Alzheimer's disease (AD) pathology and oxidative stress markers, and levels of neurotrophic factors in the rat model of AD. The rats were assigned to control, Alzheimer model, Alzheimer + voluntary exercise, Alzheimer + involuntary exercise, or Alzheimer + forced exercise group. The rat model of AD was established by D-(+)-Galactose (D-GAL) and AICl(3) administration for 90 days. Voluntary, involuntary (swimming) or forced exercise (load-swimming) trainings were performed for 90 days starting with the D-GAL and AlCl3 administration and then several behavioral tests were applied. Locomotor activity, exploratory behavior, and spatial memory were lower but anxiety levels were higher in the Alzheimer model group, than in the other groups (P < 0.05). The hippocampal levels of the amyloid beta 1-42, microtubule associated protein Tau, malondialdehyde, and protein carbonyl levels were higher, but brain-derived neurotrophic factor, nerve growth factor, glutathione and superoxide dismutase levels were lower in the Alzheimer model group, than in the other groups (P < 0.05). The results of the present study suggest that all exercise modalities almost equally attenuated non-cognitive and cognitive disturbances in a rat model of AD. Elevated neurotrophic factors, and improved oxidative stress could mediate these beneficial effects.en_US
dc.identifier.citationBelviranlı, M., Okudan, N. (2019). Voluntary, Involuntary and Forced Exercises Almost Equally Reverse Behavioral Impairment by Regulating Hippocampal Neurotrophic Factors and Oxidative Stress in Experimental Alzheimer's Disease Model. Behavioural Brain Research, 364, 245-255.
dc.identifier.doi10.1016/j.bbr.2019.02.030en_US
dc.identifier.endpage255en_US
dc.identifier.issn0166-4328en_US
dc.identifier.issn1872-7549en_US
dc.identifier.pmid30790584en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage245en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.bbr.2019.02.030
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38385
dc.identifier.volume364en_US
dc.identifier.wosWOS:000463130800027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBelviranli, Muaz.
dc.institutionauthorOkudan, Nilsel.
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofBEHAVIOURAL BRAIN RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectVoluntary exerciseen_US
dc.subjectInvoluntary exerciseen_US
dc.subjectForced exerciseen_US
dc.subjectOxidative stressen_US
dc.subjectNeurotrophic factorsen_US
dc.titleVoluntary, involuntary and forced exercises almost equally reverse behavioral impairment by regulating hippocampal neurotrophic factors and oxidative stress in experimental Alzheimer's disease modelen_US
dc.typeArticleen_US

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